| Comparison of urinary modified nucleosides and bases in rats with hepatomas and nephroblastomas. | |
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MedLine Citation:
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PMID: 6302750 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Hepatomas were induced in rats with aflatoxin B1, and nephroblastomas with dimethylnitrosamine. Microscopic examination of livers of aflatoxin-treated rats revealed multinodular hepatocyte hyperplasia at 8 months, and by 13 months all rats had hepatomas. Nephroblastomas were observed by 4 months and by 8 months all rats had developed them. The urinary excretion of several modified nucleosides and bases by normal rats is dependent on body weight and reflects, to a certain extent, their concentrations in tissue tRNA. Increased levels of several modified nucleosides and bases were found in all rats that had cancer. Rats with hepatomas excreted essentially the same modified nucleosides and bases as did those with nephroblastomas; the quantitative patterns of excretion were different, however, suggesting that the urinary modified nucleosides and bases may be used to differentiate between neoplasms. Although the increase in urinary modified nucleosides and bases by tumor-bearing animals results primarily from more rapid turnover of neoplastic tRNAs, the data indicate that increased turnover of mRNA and possibly rRNA may occur in neoplastic tissue. Preliminary data suggest that increases in urinary modified nucleosides and bases may occur during a precancerous stage. The urinary pattern of modified nucleosides and bases by rats with hepatomas is altered if another primary tumor is present. The results obtained from these studies support the use of modified nucleosides and bases in urine as biochemical markers of cancer. |
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Authors:
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I Clark; J W MacKenzie; J R McCoy; W Lin |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Recent results in cancer research. Fortschritte der Krebsforschung. Progrès dans les recherches sur le cancer Volume: 84 ISSN: 0080-0015 ISO Abbreviation: Recent Results Cancer Res. Publication Date: 1983 |
Date Detail:
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Created Date: 1983-06-10 Completed Date: 1983-06-10 Revised Date: 2008-02-13 |
Medline Journal Info:
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Nlm Unique ID: 0044671 Medline TA: Recent Results Cancer Res Country: GERMANY, WEST |
Other Details:
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Languages: eng Pagination: 388-400 Citation Subset: IM |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aflatoxin B1 Aflatoxins Animals Deoxyribonucleosides / urine Dimethylnitrosamine Kidney Neoplasms / urine* Liver Neoplasms, Experimental / urine* Male Neoplasms, Experimental / urine Nucleosides / urine* Purines / urine* Pyrimidines / urine* Rats Rats, Inbred Strains Ribonucleosides / urine Wilms Tumor / urine* |
| Chemical | |
Reg. No./Substance:
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0/Aflatoxins; 0/Deoxyribonucleosides; 0/Nucleosides; 0/Purines; 0/Pyrimidines; 0/Ribonucleosides; 1162-65-8/Aflatoxin B1; 62-75-9/Dimethylnitrosamine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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