Document Detail


Comparison of uptake between PureSorb-Q40 and regular hydrophobic coenzyme Q10 in rats and humans after single oral intake.
MedLine Citation:
PMID:  17616008     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Coenzyme Q10 (CoQ10) is a lipid-soluble antioxidant and essential component of the mitochondrial electron transfer system in the body, and is in wide use as a functional food material and cosmetic raw material. However, as CoQ10 is extremely lipid-soluble, absorption by the body is not easy. In general, people use soft-gel capsules in which CoQ10 is suspended in oil, and take these capsules with food. PureSorb-Q40 (P40) was developed to improve CoQ10 processability and absorption when taken without food, and the present study compared the effects of food on absorption between P40 and conventional lipid-soluble CoQ10 in rats and humans. The results of a rat study showed higher uptake when P40 was administered in the fasting state or with food compared to lipid-soluble CoQ10. The results of a human study showed that uptake was favorable when P40 was administered in the fasting state, and even when administered postprandially, a significant difference was noted in uptake rate up to 6 h after intake and uptake volume up to 8 h after intake when compared to lipid-soluble CoQ10. These results show that any CoQ10 product using P40 can be quickly and reliably absorbed by the body regardless of dosage form or intake time.
Authors:
Kazuki Nukui; Toshihiko Yamagishi; Hiromi Miyawaki; Aikkarach Kettawan; Tadashi Okamoto; Kiyoshi Sato
Related Documents :
20149118 - A systematic review of fast food access studies.
23409268 - Draft genome sequence of a clostridium botulinum isolate from water used for cooling at...
14982768 - Pharmacokinetics of posaconazole coadministered with antacid in fasting or nonfasting h...
19818868 - Selection of physiological and metabolic adaptations to food deprivation in the pyrenea...
16233408 - Chitosan productivity enhancement in rhizopus oryzae ypf-61a by d-psicose.
1955818 - Effects of d-amphetamine on responding under second-order schedules of reinforcement wi...
Publication Detail:
Type:  Comparative Study; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Journal of nutritional science and vitaminology     Volume:  53     ISSN:  0301-4800     ISO Abbreviation:  J. Nutr. Sci. Vitaminol.     Publication Date:  2007 Apr 
Date Detail:
Created Date:  2007-07-09     Completed Date:  2007-08-28     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0402640     Medline TA:  J Nutr Sci Vitaminol (Tokyo)     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  187-90     Citation Subset:  IM    
Affiliation:
Nisshin Pharma Inc., 25, Kanda-Nishiki-cho 1-chome, Chiyoda-ku, Tokyo 101-8441, Japan. nukuik@mail.ni-net.co.jp
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Administration, Oral
Adult
Animals
Antioxidants / administration & dosage,  metabolism,  pharmacokinetics*
Capsules
Chromatography, High Pressure Liquid / methods
Coenzymes / administration & dosage,  blood,  metabolism,  pharmacokinetics*
Cross-Over Studies
Food
Humans
Hydrophobicity
Male
Random Allocation
Rats
Rats, Sprague-Dawley
Reference Values
Tablets
Time Factors
Ubiquinone / administration & dosage,  analogs & derivatives*,  blood,  pharmacokinetics
Vitamins / administration & dosage,  blood,  pharmacokinetics*
Chemical
Reg. No./Substance:
0/Antioxidants; 0/Capsules; 0/Coenzymes; 0/PureSorb-Q40; 0/Tablets; 0/Vitamins; 1339-63-5/Ubiquinone; 303-98-0/coenzyme Q10

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Purification and characterization of corrinoid-compounds from the dried powder of an edible cyanobac...
Next Document:  Workplace colorectal cancer-screening awareness programs: an adjunct to primary care practice?