Document Detail

Comparison of umbilical cord interlukin-8 in low birth weight infants with premature rupture of membranes and intact membranes.
MedLine Citation:
PMID:  19943468     Owner:  NLM     Status:  MEDLINE    
Some studies showed increased levels ofproinflammatory cytokines like IL-6, IL-8 and TNF-alpha in the blood samples of pregnant women with PROM (Premature rupture of membranes) and their neonates. The aim of this study was to find a relationship between increased level of IL-8 and PROM, a cost benefit method for early diagnosis and reduction of hospitalization period of neonatal sepsis. This case control study was conducted in Obstetrics and Gynecology Department of Al-Zahra Hospital at Tabriz University of Medical Sciences, Iran from 10th April 2001 to 20th June 2003. We studied 50 LBW (Low birth weight) neonates born from mothers with PROM as the case group and fifty LBW neonates born from mothers without PROM as our control group Neonates born from pregnant women with PROM underwent sepsis workup and blood samples from their umbilical cord were sent for blood culture and IL-8 level measurement. Mean levels of IL-8 in study and control groups were 128.12 and 39.2 pg mL(-1), respectively. We had no positive blood culture and no bacteria could be isolated. Significantly elevated values (p<0.0003) were showed in cases with PROM compared to cases without PROM (medians 67.5 pg mL(-1) vs. 29.5 pg mL(-1), respectively). This study showed a strong relationship between IL-8 elevation and PROM. Increased levels of IL-8 can be used as indicator for early diagnosis of neonatal sepsis.
N Najati; M Rafeey; Taghy Melekian
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Pakistan journal of biological sciences: PJBS     Volume:  12     ISSN:  1028-8880     ISO Abbreviation:  Pak. J. Biol. Sci.     Publication Date:  2009 Aug 
Date Detail:
Created Date:  2009-11-30     Completed Date:  2010-01-05     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101247723     Medline TA:  Pak J Biol Sci     Country:  Pakistan    
Other Details:
Languages:  eng     Pagination:  1094-7     Citation Subset:  IM    
Department of Neonatology, Children General Hospital, Tabriz University of Medical Sciences, Tabriz, Iran.
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MeSH Terms
Case-Control Studies
Extraembryonic Membranes* / immunology
Fetal Blood / immunology*
Fetal Membranes, Premature Rupture / blood*,  diagnosis,  immunology*
Gestational Age
Infant, Low Birth Weight* / blood,  immunology
Infant, Newborn
Interleukin-8 / blood*
Sepsis / blood,  diagnosis,  immunology
Reg. No./Substance:

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