Document Detail

Comparison of ultrasonically nebulized distilled water and cold-air hyperventilation challenges in asthmatic patients.
MedLine Citation:
PMID:  2495907     Owner:  NLM     Status:  MEDLINE    
Cold-air hyperventilation (CAHC) and ultrasonically nebulized distilled water (UNDW) challenges were compared in 11 asthmatic patients who were moderately sensitive to methacholine. The challenges were performed on two separate days within one week of each other. Baseline FEV1 on each test day was greater than 70 percent of predicted. Ten of 11 subjects' FEV1 decreased at least 15 percent, and nine of 11 decreased at least 20 percent during the UNDW. Ten of 11 subjects' FEV1 decreased at least 10 percent, and eight of 11 decreased at least 15 percent during the CAHC. Using a Spearman rank coefficient, the results of the CAHC and UNDW were compared; the best correlation between the various CAHC and UNDW measurements equaled only 0.51. The correlation between UNDW and CAHC suggests that the mechanism of action of each challenge may be different.
T S Lemire; R J Hopp; A K Bewtra; N M Nair; R G Townley
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Chest     Volume:  95     ISSN:  0012-3692     ISO Abbreviation:  Chest     Publication Date:  1989 May 
Date Detail:
Created Date:  1989-06-05     Completed Date:  1989-06-05     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0231335     Medline TA:  Chest     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  958-61     Citation Subset:  AIM; IM    
Allergic Disease Center, Creighton University, Omaha 68178.
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MeSH Terms
Asthma / physiopathology*
Bronchial Provocation Tests / methods*
Carbon Dioxide
Cold Temperature / diagnostic use*
Forced Expiratory Volume
Nebulizers and Vaporizers
Ultrasonics / instrumentation
Water / administration & dosage,  diagnostic use*
Grant Support
Reg. No./Substance:
0/Aerosols; 124-38-9/Carbon Dioxide; 7732-18-5/Water

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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