Document Detail


Comparison of the ulcerogenic properties of tepoxalin with those of non-steroidal anti-inflammatory drugs (NSAIDs).
MedLine Citation:
PMID:  1793039     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The ability of tepoxalin to render the gastric mucosa susceptible to injury by a topically applied irritant was compared to that of indomethacin, naproxen and diclofenac. While the three NSAIDs significantly increased the extent of mucosal damage at doses in the 1-30 mg/kg range, tepoxalin failed to significantly augment damage at doses of up to 300 mg/kg. Daily treatment with tepoxalin (10-100 mg/kg) for 4 days also did not significantly affect the susceptibility of the gastric mucosa to damage. The absence of ulcerogenic properties of tepoxalin at doses previously shown to be anti-inflammatory may be related to its relative lack of activity as an inhibitor of gastric prostaglandin synthesis, or to its 5-lipoxygenase inhibitory activity.
Authors:
J L Wallace; G Cirino; C Cicala; D W Anderson; D Argentieri; R J Capetola
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Agents and actions     Volume:  34     ISSN:  0065-4299     ISO Abbreviation:  Agents Actions     Publication Date:  1991 Sep 
Date Detail:
Created Date:  1992-03-31     Completed Date:  1992-03-31     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0213341     Medline TA:  Agents Actions     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  247-50     Citation Subset:  IM    
Affiliation:
Gastrointestinal Research Group, University of Calgary, Alberta, Canada.
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MeSH Terms
Descriptor/Qualifier:
Animals
Anti-Inflammatory Agents, Non-Steroidal / toxicity*
Gastric Mucosa / drug effects
Male
Pyrazoles / toxicity*
Rats
Rats, Inbred Strains
Species Specificity
Stomach Ulcer / chemically induced*
Chemical
Reg. No./Substance:
0/Anti-Inflammatory Agents, Non-Steroidal; 0/Pyrazoles; 103475-41-8/tepoxalin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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