Document Detail

Comparison of type I and type II bovine viral diarrhea virus infection in swine.
MedLine Citation:
PMID:  10369569     Owner:  NLM     Status:  MEDLINE    
Some isolates of type II bovine viral diarrhea virus (BVDV) are capable of causing severe clinical disease in cattle. Bovine viral diarrhea virus infection has been reported in pigs, but the ability of these more virulent isolates of type II BVDV to induce severe clinical disease in pigs is unknown. It was our objective to compare clinical, virologic, and pathologic findings between type I and type II BVDV infection in pigs. Noninfected control and BVDV-infected 2-month-old pigs were used. A noncytopathic type I and a noncytopathic type II BVDV isolate were chosen for evaluation in feeder age swine based upon preliminary in vitro and in vivo experiments. A dose titration study was performed using 4 groups of 4 pigs for each viral isolate. The groups were inoculated intranasally with either sham (control), 10(3), 10(5), or 10(7) TCID50 of virus. The pigs were examined daily and clinical findings were recorded. Antemortem and postmortem samples were collected for virus isolation. Neither the type I nor type II BVDV isolates resulted in clinical signs of disease in pigs. Bovine viral diarrhea virus was isolated from antemortem and postmortem samples from groups of pigs receiving the 10(5) and the 10(7) TCID50 dose of the type I BVDV isolate. In contrast, BVDV was only isolated from postmortem samples in the group of pigs receiving the 10(7) TCID50 dose of the type II BVDV isolate. Type I BVDV was able to establish infection in pigs at lower doses by intranasal instillation than type II BVDV. Infection of pigs with a type II isolate of BVDV known to cause severe disease in calves did not result in clinically apparent disease in pigs.
P H Walz; J C Baker; T P Mullaney; J B Kaneene; R K Maes
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Canadian journal of veterinary research = Revue canadienne de recherche vétérinaire     Volume:  63     ISSN:  0830-9000     ISO Abbreviation:  Can. J. Vet. Res.     Publication Date:  1999 Apr 
Date Detail:
Created Date:  1999-06-28     Completed Date:  1999-06-28     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  8607793     Medline TA:  Can J Vet Res     Country:  CANADA    
Other Details:
Languages:  eng     Pagination:  119-23     Citation Subset:  IM    
Department of Large Animal Clinical Sciences, Michigan State University, East Lansing 48824-1314, USA.
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MeSH Terms
Bovine Virus Diarrhea-Mucosal Disease / pathology,  physiopathology*
Diarrhea Viruses, Bovine Viral / classification*,  genetics,  isolation & purification
Ileum / pathology,  virology
Lung / pathology,  virology
Lymph Nodes / pathology,  virology
Palatine Tonsil / pathology,  virology
Spleen / pathology,  virology

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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