Document Detail

Comparison of two regimens for the treatment of meningoencephalomyelitis of unknown etiology.
MedLine Citation:
PMID:  19645837     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: The optimal treatment for meningoencephalomyelitis of unknown etiology (MUE) remains unknown, despite the widespread use of a variety of immunosuppressive drugs. OBJECTIVE/HYPOTHESIS: To compare the efficacy of prednisolone combined with either vincristine and cyclophosphamide (COP group; n= 10) or with cytosine arabinoside (AraC group; n= 9). ANIMALS: Nineteen dogs with neurological deficits, neuroimaging, and cerebrospinal fluid abnormalities consistent with a diagnosis of MUE. METHODS: Prospective, blinded, and randomized clinical trial. Dogs fulfilling the inclusion criteria were randomly allocated to receive 1 drug regimen. RESULTS: Four of 10 dogs in the COP group and 5/9 in the AraC group survived > 12 months but neither the survival time nor the time-to-treatment failure differed between the 2 groups. Treatment with COP resulted in an unacceptable incidence of adverse effects. CONCLUSIONS: The adverse effects of COP make it an unsuitable treatment for MUE. Although survival of animals treated with AraC was broadly similar to that reported in recently published studies describing this treatment, it remains unclear whether it confers any benefit over using prednisolone alone.
P M Smith; C E Stalin; D Shaw; N Granger; N D Jeffery
Related Documents :
12804437 - Medical adjuvant treatment to increase patency of arteriovenous fistulae and grafts.
10796677 - Intravenous naftidrofuryl for critical limb ischaemia.
12790387 - Development of a database of patients supported by ventricular assist devices.
1919317 - Prospective study of the use of vasoconstrictor and saline in septal surgery for infilt...
24113197 - Effect of raloxifene on disease activity and vascular biomarkers in patients with syste...
17674587 - Current and emerging therapeutic modalities for hyperhidrosis, part 1: conservative and...
Publication Detail:
Type:  Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Journal of veterinary internal medicine / American College of Veterinary Internal Medicine     Volume:  23     ISSN:  0891-6640     ISO Abbreviation:  J. Vet. Intern. Med.     Publication Date:    2009 May-Jun
Date Detail:
Created Date:  2009-08-03     Completed Date:  2009-11-09     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8708660     Medline TA:  J Vet Intern Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  520-6     Citation Subset:  IM    
Department of Veterinary Medicine, The Queen's Veterinary School Hospital, University of Cambridge, Cambridge, UK.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Antineoplastic Agents / adverse effects,  therapeutic use*
Dog Diseases / drug therapy*
Drug Therapy, Combination
Immunosuppressive Agents / administration & dosage,  adverse effects,  therapeutic use*
Meningoencephalitis / drug therapy,  veterinary*
Treatment Failure
Reg. No./Substance:
0/Antineoplastic Agents; 0/Immunosuppressive Agents

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Combination therapy with digoxin and diltiazem controls ventricular rate in chronic atrial fibrillat...
Next Document:  Magnetic resonance imaging characteristics of necrotizing meningoencephalitis in pug dogs.