Document Detail


Comparison of two regimens for the treatment of meningoencephalomyelitis of unknown etiology.
MedLine Citation:
PMID:  19645837     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: The optimal treatment for meningoencephalomyelitis of unknown etiology (MUE) remains unknown, despite the widespread use of a variety of immunosuppressive drugs. OBJECTIVE/HYPOTHESIS: To compare the efficacy of prednisolone combined with either vincristine and cyclophosphamide (COP group; n= 10) or with cytosine arabinoside (AraC group; n= 9). ANIMALS: Nineteen dogs with neurological deficits, neuroimaging, and cerebrospinal fluid abnormalities consistent with a diagnosis of MUE. METHODS: Prospective, blinded, and randomized clinical trial. Dogs fulfilling the inclusion criteria were randomly allocated to receive 1 drug regimen. RESULTS: Four of 10 dogs in the COP group and 5/9 in the AraC group survived > 12 months but neither the survival time nor the time-to-treatment failure differed between the 2 groups. Treatment with COP resulted in an unacceptable incidence of adverse effects. CONCLUSIONS: The adverse effects of COP make it an unsuitable treatment for MUE. Although survival of animals treated with AraC was broadly similar to that reported in recently published studies describing this treatment, it remains unclear whether it confers any benefit over using prednisolone alone.
Authors:
P M Smith; C E Stalin; D Shaw; N Granger; N D Jeffery
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Journal of veterinary internal medicine / American College of Veterinary Internal Medicine     Volume:  23     ISSN:  0891-6640     ISO Abbreviation:  J. Vet. Intern. Med.     Publication Date:    2009 May-Jun
Date Detail:
Created Date:  2009-08-03     Completed Date:  2009-11-09     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8708660     Medline TA:  J Vet Intern Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  520-6     Citation Subset:  IM    
Affiliation:
Department of Veterinary Medicine, The Queen's Veterinary School Hospital, University of Cambridge, Cambridge, UK. pms24@liv.ac.uk
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MeSH Terms
Descriptor/Qualifier:
Animals
Antineoplastic Agents / adverse effects,  therapeutic use*
Dog Diseases / drug therapy*
Dogs
Drug Therapy, Combination
Immunosuppressive Agents / administration & dosage,  adverse effects,  therapeutic use*
Meningoencephalitis / drug therapy,  veterinary*
Treatment Failure
Chemical
Reg. No./Substance:
0/Antineoplastic Agents; 0/Immunosuppressive Agents

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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