Document Detail

Comparison of brimonidine/latanoprost and timolol/dorzolamide: two randomized, double-masked, parallel clinical trials.
MedLine Citation:
PMID:  12836809     Owner:  NLM     Status:  MEDLINE    
Two double-masked, randomized, parallel, multicenter trials of similar design were conducted to compare the IOP-lowering efficacy of dual therapy with brimonidine 0.2% and latanoprost 0.005% with the fixed combination of timolol 0.5%/dorzolamide 2% in patients with glaucoma or ocular hypertension. The combination of brimonidine and latanoprost produced significantly greater mean IOP reductions at each visit in both trials. In study 1, the mean reduction at peak drug effect after 6 weeks was 9.2 mm Hg (34.7%) with brimonidine and latanoprost and 6.7 mm Hg (26.1%) with timolol/dorzolamide (P=.024); respective reductions at week 12 were 9.0 mm Hg (33.9%) and 6.5 mm Hg (25.3%) (P=.044). At the month 1 visit in study 2, the mean peak IOP reduction was 10.6 mm Hg (39.0%) with dual therapy and 6.3 mm Hg (25.1%) with the fixed combination (P=.001). After 3 months, reductions were 9.1 mm Hg (33.4%) and 6.6 mm Hg (26.3%) (P=.047). In these studies, the combination of brimonidine and latanoprost provided IOP control superior to that of the fixed combination of timolol/dorzolamide.
Norman Zabriskie; Peter A Netland;
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Multicenter Study; Randomized Controlled Trial    
Journal Detail:
Title:  Advances in therapy     Volume:  20     ISSN:  0741-238X     ISO Abbreviation:  Adv Ther     Publication Date:    2003 Mar-Apr
Date Detail:
Created Date:  2003-07-02     Completed Date:  2003-08-13     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8611864     Medline TA:  Adv Ther     Country:  United States    
Other Details:
Languages:  eng     Pagination:  92-100     Citation Subset:  T    
John A. Moran Eye Center, University of Utah, Salt Lake City, Utah, USA.
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MeSH Terms
Antihypertensive Agents / administration & dosage,  adverse effects,  therapeutic use*
Double-Blind Method
Drug Therapy, Combination
Exfoliation Syndrome / drug therapy*,  physiopathology
Glaucoma, Open-Angle / drug therapy*,  physiopathology
Intraocular Pressure / drug effects
Middle Aged
Ocular Hypertension / drug therapy*,  physiopathology
Patient Satisfaction / statistics & numerical data
Prostaglandins F, Synthetic / administration & dosage,  adverse effects,  therapeutic use*
Quinoxalines / administration & dosage,  adverse effects,  therapeutic use*
Sulfonamides / administration & dosage,  adverse effects,  therapeutic use*
Thiophenes / administration & dosage,  adverse effects,  therapeutic use*
Timolol / administration & dosage,  adverse effects,  therapeutic use*
Treatment Outcome
Reg. No./Substance:
0/Antihypertensive Agents; 0/Prostaglandins F, Synthetic; 0/Quinoxalines; 0/Sulfonamides; 0/Thiophenes; 130209-82-4/latanoprost; 130693-82-2/dorzolamide; 26839-75-8/Timolol; 59803-98-4/brimonidine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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