Document Detail

Comparison of two plethysmography systems in assessment of forearm blood flow.
MedLine Citation:
PMID:  14752120     Owner:  NLM     Status:  MEDLINE    
Venous occlusion plethysmography is widely used to assess forearm blood flow (FBF). We compared the established Hokanson system (HEC4) with a newly developed Filtrass 2001 system (F2001). The HEC4 uses mercury-in-Silastic strain gauges, whereas F2001 detects volume changes with a nonmercury linear displacement device. The aim of this study was to evaluate the new F2001 against the HEC4 in terms of repeatability and systematic bias. Ten subjects were studied on 4 separate days in random order using either the HEC4 on both arms, the F2001 on both arms, the HEC4 on the right arm with the F2001 on the left, or the F2001 on the right arm and the HEC4 on the left. Stroop's colored word conflict test and postocclusive hyperemia were used to increase FBF, and lower body negative pressure was used to lower FBF. Stroop's colored word conflict test and lower body negative pressure increased (24.6 +/- 1.5%, n = 240, P < 0.0001) and decreased (18.7 +/- 0.8%, n = 240, P < 0.0001) FBF, respectively. Postocclusive hyperemia after occlusion times of 5, 8, and 13 min substantially increased FBF by 390 +/- 86, 756 +/- 217, and 851 +/- 132%, respectively. Repeatability was not different between the devices (0.10 +/- 2.37 vs. -0.47 +/- 1.92 l/min, n = 125, P > 0.05), and there was no systematic bias. The F2001 is a newly developed plethysmography system that does not utilize mercury and is suitable for assessing changes of FBF in physiological studies.
Stephen J Leslie; Teresa Attinà; Ellen Hultsch; Luc Bolscher; Matthias Grossman; Martin A Denvir; David J Webb
Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't     Date:  2004-01-29
Journal Detail:
Title:  Journal of applied physiology (Bethesda, Md. : 1985)     Volume:  96     ISSN:  8750-7587     ISO Abbreviation:  J. Appl. Physiol.     Publication Date:  2004 May 
Date Detail:
Created Date:  2004-04-12     Completed Date:  2004-12-14     Revised Date:  2013-09-26    
Medline Journal Info:
Nlm Unique ID:  8502536     Medline TA:  J Appl Physiol (1985)     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1794-9     Citation Subset:  IM    
Clinical Pharmacology Unit & Research Centre, The University of Edinburgh, Western General Hospital, Edinburgh, UK EH4 2XU.
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MeSH Terms
Equipment Design
Forearm / blood supply*
Hyperemia / etiology,  physiopathology
Lower Body Negative Pressure
Plethysmography / instrumentation*,  standards
Regional Blood Flow
Reproducibility of Results
Stress, Psychological

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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