Document Detail

Comparison of two neonatal intravenous amino acid formulations in preterm infants: a multicenter study.
MedLine Citation:
PMID:  1770397     Owner:  NLM     Status:  MEDLINE    
Two neonatal intravenous amino acid solutions (Aminosyn-PF and Troph-Amine) were compared in 44 preterm infants. The rate of weight gain, nitrogen balance, and changes in plasma aminograms were determined over 7 days to ascertain whether different outcomes could be identified for the two solutions. At study entry, the infants received a minimum infusion of 2 g amino acid/kg/d with 50 or more nonprotein kcal/kg/d. Group mean amino acid intake over the study period was approximately 2.6 g/kg/d for both groups; nonprotein caloric intake approximated 90 kcal/kg/d. Results showed no significant differences between solutions for the rate of weight gain, nitrogen balance, and nitrogen retention, which approximated intrauterine rates. The rate of weight gain averaged nearly 15 g/kg/d for both solutions. Differences between day 0 and day 7 plasma aminograms showed significant changes between solutions for histidine, lysine, methionine, phenylalanine, threonine, and glutamic acid. However, day 7 plasma aminograms for both solutions compared favorably with those from enterally fed preterm infants reported in the literature. Failure to identify significant differences for the rate of weight gain, nitrogen balance, or nitrogen retention between the two groups suggests that differences in plasma aminograms resulting from use of one solution or the other had no short-term clinical consequences in the premature infants studied.
D H Adamkin; R E McClead; N S Desai; K M McCulloch; M B Marchildon
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Controlled Clinical Trial; Journal Article; Multicenter Study    
Journal Detail:
Title:  Journal of perinatology : official journal of the California Perinatal Association     Volume:  11     ISSN:  0743-8346     ISO Abbreviation:  J Perinatol     Publication Date:  1991 Dec 
Date Detail:
Created Date:  1992-02-27     Completed Date:  1992-02-27     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8501884     Medline TA:  J Perinatol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  375-82     Citation Subset:  IM    
Department of Pediatrics, University of Louisville, Kentucky.
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MeSH Terms
Amino Acids* / administration & dosage*,  analysis,  blood
Blood Proteins / analysis
Energy Intake
Food, Formulated*
Infant Food*
Infant, Newborn
Infant, Premature* / blood,  growth & development*
Nitrogen / urine
Parenteral Nutrition, Total / methods*
Prospective Studies
Weight Gain
Reg. No./Substance:
0/Amino Acids; 0/Blood Proteins; 65072-01-7/Travasol; 7727-37-9/Nitrogen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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