| Comparison of two methods of delivering continuously nebulized albuterol. | |
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MedLine Citation:
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PMID: 12503928 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To compare the relative delivery of 2 methods for providing continuously nebulized albuterol (CNA): a small-volume nebulizer plus infusion pump versus a large-volume nebulizer. DESIGN: An open, randomized comparison of 3 hours of CNA administration using an in vitro lung model with a follow-up particle size assessment of the large-volume nebulizer. METHODS: Six different nebulizers of each type were connected to a lung model via a volume-limited mechanical ventilator and infant ventilator circuitry. Albuterol was nebulized at 10 mg/h for 3 hours in random order. The small-volume nebulizer used was the Airlife Misty Neb (Baxter, Valencia, CA); the large-volume nebulizer was the HEART Nebulizer (Vortran Medical, Orangevale, CA). One large-volume nebulizer was operated over 8 hours for the output and particle sizing study. RESULTS: The small-volume nebulizer delivered a greater amount of albuterol (mean +/- SD percentage of total nebulized) to the model lung (5.75 +/- 1.38% vs. 4.12 +/- 0.67%; p < 0.025) than the large-volume nebulizer, but demonstrated greater variability. Although total output was not maintained after 8 hours of nebulization with the large-volume nebulizer, the percent of particles in the respirable range remained consistent. CONCLUSIONS: The large-volume nebulizer evaluated in this study maintains consistent output up to 8 hours and provides an acceptable method for delivering CNA through an infant ventilator circuit. |
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Authors:
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H William Kelly; Kerry A Keim; Bennie C McWilliams |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: The Annals of pharmacotherapy Volume: 37 ISSN: 1060-0280 ISO Abbreviation: Ann Pharmacother Publication Date: 2003 Jan |
Date Detail:
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Created Date: 2002-12-30 Completed Date: 2003-04-24 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 9203131 Medline TA: Ann Pharmacother Country: United States |
Other Details:
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Languages: eng Pagination: 23-6 Citation Subset: IM |
Affiliation:
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Department of Pediatrics, University of New Mexico Health Sciences Center, Albuquerque, NM 87131-5311, USA. hwkelly@unm.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Administration, Inhalation Aerosols Albuterol / administration & dosage* Bronchodilator Agents / administration & dosage* Equipment Design Humans Infant Infusion Pumps Models, Structural Nebulizers and Vaporizers* Respiration, Artificial |
| Grant Support | |
ID/Acronym/Agency:
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N01HR16046/HR/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Aerosols; 0/Bronchodilator Agents; 18559-94-9/Albuterol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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