| Comparison of two induction regimens using or not using muscle relaxant: impact on postoperative upper airway discomfort. | |
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MedLine Citation:
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PMID: 17573390 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Muscle relaxants facilitate tracheal intubation, but they are often not used for short peripheral surgical procedures. The consequences of this practice on the upper airway are still a matter of controversy. We therefore compared the incidence of post-intubation symptoms in a randomized study comparing patients intubated with or without the use of a muscle relaxant. METHODS: A total of 300 adult patients requiring tracheal intubation for scheduled peripheral surgery were randomly assigned in a double-blind study to an anaesthetic protocol that either included or did not include a muscle relaxant (rocuronium). The primary end-point was the rate of post-intubation symptoms 2 and 24 h after extubation. The secondary end-points were the intubation conditions score (Copenhagen Consensus Conference), the rate of difficult intubations (Intubation Difficulty Scale), and the incidence of adverse haemodynamic events. RESULTS: Post-intubation symptoms were more frequent in patients intubated without the use of a muscle relaxant, whether 2 h (57% vs 43% of patients; P < 0.05) or 24 h (38% vs 26% of patients; P < 0.05) after extubation. Intubation conditions were better when the muscle relaxant was used. In patients intubated without a muscle relaxant, difficult intubation was more common (12% vs 1%; P < 0.05), as were arterial hypotension or bradycardia requiring treatment (12% vs 3% of patients; P < 0.05). CONCLUSIONS: The use of a muscle relaxant for tracheal intubation diminishes the incidence of adverse postoperative upper airway symptoms, results in better tracheal intubation conditions, and reduces the rate of adverse haemodynamic events. |
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Authors:
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X Combes; L Andriamifidy; E Dufresne; P Suen; S Sauvat; E Scherrer; P Feiss; J Marty; P Duvaldestin |
Publication Detail:
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Type: Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't Date: 2007-06-15 |
Journal Detail:
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Title: British journal of anaesthesia Volume: 99 ISSN: 0007-0912 ISO Abbreviation: Br J Anaesth Publication Date: 2007 Aug |
Date Detail:
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Created Date: 2007-07-09 Completed Date: 2007-08-21 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0372541 Medline TA: Br J Anaesth Country: England |
Other Details:
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Languages: eng Pagination: 276-81 Citation Subset: IM |
Affiliation:
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Department of Anesthesia, Henri Mondor Hospital (APHP), 51 avenue du Maréchal de Lattre-de-Tassigny, 94100 Créteil cedex, France. xavier.combes@hmn.ap-hop-paris.fr |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Aged Androstanols* Blood Pressure Double-Blind Method Female Heart Rate Humans Intubation, Intratracheal / adverse effects*, methods Male Middle Aged Neuromuscular Nondepolarizing Agents* Pharyngitis / etiology* Postoperative Complications Prospective Studies |
| Chemical | |
Reg. No./Substance:
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0/Androstanols; 0/Neuromuscular Nondepolarizing Agents; 143558-00-3/rocuronium |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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