| Comparison of two hyaluronan drugs in patients with advanced osteoarthritis of the knee. A prospective, randomized, double-blind study with long term follow-up. | |
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MedLine Citation:
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PMID: 15895892 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVES: To compare the long-term effects of high and low molecular weight hyaluronic acid (HA) applications in severe (Kellgren Lawrence stage III) osteoarthritis (OA) of the knee. METHODS: In a prospective clinical trial 184 knees (92 patients) with radiographic Kellgren Lawrence stage III OA were randomized to receive either 3 intra-articular high molecular weight HA (Hylan G-F 20) injections or 3 low molecular weight HA (Orthovisc) injections at one-week intervals. Patients were evaluated by the Hospital for Special Surgery (HSS) Knee Score and were followed-up for 12 months. RESULTS: The total HSS score in high molecular weight HA patients improved from 71.8+/-11.6 to 86.7+/-11.6 and in low molecular weight HA patients from 66.7+/-11.0 to 86.6+/-9.1 at the end of the trial (p < 0.01). There were no statistically significant differences between the groups and both had improved in all parameters at the latest follow-up (p = 0.000). CONCLUSIONS: Three intra-articular injections at intervals of 1 week of both HA preparations resulted in a pronounced reduction in pain and improved function as measured by the HSS score during a period of 52 weeks, without complications. |
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Authors:
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V Karatosun; B Unver; Z Gocen; A Sen |
Publication Detail:
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Type: Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial |
Journal Detail:
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Title: Clinical and experimental rheumatology Volume: 23 ISSN: 0392-856X ISO Abbreviation: Clin. Exp. Rheumatol. Publication Date: 2005 Mar-Apr |
Date Detail:
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Created Date: 2005-05-17 Completed Date: 2005-07-26 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8308521 Medline TA: Clin Exp Rheumatol Country: Italy |
Other Details:
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Languages: eng Pagination: 213-8 Citation Subset: IM |
Affiliation:
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Department of Orthopaedic Surgery, Dokuz Eylul University Hospital, Balcova, Izmir, Turkey. vasfi.karatosun@deu.edu.tr |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Double-Blind Method Female Health Status Humans Hyaluronic Acid / analogs & derivatives*, therapeutic use* Injections, Intra-Articular Male Middle Aged Molecular Weight Osteoarthritis, Knee / drug therapy*, physiopathology Pain / drug therapy, physiopathology Range of Motion, Articular Severity of Illness Index Treatment Outcome |
| Chemical | |
Reg. No./Substance:
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0/orthovisc; 125935-84-4/hylan; 9004-61-9/Hyaluronic Acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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