| Comparison of two forms of continuous combined hormone replacement therapy with respect to metabolic effects. | |
| | |
MedLine Citation:
|
PMID: 17051405 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
OBJECTIVE: To compare the metabolic effects of two frequently used continuous hormone replacement therapies. MATERIALS AND METHODS: Two hundred and forty-six menopausal women, aged between 41 and 57 years were enrolled in the present study. They were randomized to receive either estrogen + 2.5 mg medroxyprogesterone acetate (CEE/MPA) or 1 mg 17 <beta> estradiol + 0.5 mg norethindrone acetate (E2/NETA). Women in group I (n = 139) and group II (n = 107) were followed up for 1 year and compared with respect to total cholesterol, triglycerides, HDL, LDL, VLDL, weight gain during this period. RESULTS: The basal and 12th month weight of the patients of two groups were not statistically different (P = 0.57 and P = 0.17, respectively, in the groups I and II). No changes were detected in the levels of triglycerides, HDL and VLDL, while total cholesterol (P = 0.01) and LDL (P = 0.003) levels significantly decreased in the CEE/MPA group. In group 2, total cholesterol and triglyceride levels showed no significant change, however, levels of HDL cholesterol (P = 0.001) increased and LDL (P = 0.001) and VLDL cholesterol (P = 0.006) decreased significantly. CONCLUSION: Administration of E2/NETA regimen has better results on lipid profile when compared to CEE/MPA regimen. No weight gain is recorded in E2/NETA group. |
| | |
Authors:
|
Semih Tugrul; Gazi Yildirim; Oya Pekin; Hüsamettin Uslu; Tayfun Kutlu; Sadiye Eren |
Related Documents
:
|
7087795 - Effects of aoma on cholesterol metabolism in man. 8017305 - Effects of heparin and cardiac catheterization on serum lipoprotein and triglyceride le... 3069765 - Effects of fenfluramine in hypertriglyceridemic obese subjects. 12837045 - Orlistat use in overweight women with mild hypercholesterolemia. 21614505 - A comparison of dual energy x-ray absorptiometry and bioelectrical impedance analysis t... 21784375 - The relationship between body mass index and the variation in plasma levels of triglyce... |
Publication Detail:
|
Type: Journal Article; Randomized Controlled Trial Date: 2006-10-19 |
Journal Detail:
|
Title: Archives of gynecology and obstetrics Volume: 275 ISSN: 0932-0067 ISO Abbreviation: Arch. Gynecol. Obstet. Publication Date: 2007 May |
Date Detail:
|
Created Date: 2007-03-22 Completed Date: 2007-11-08 Revised Date: 2009-11-19 |
Medline Journal Info:
|
Nlm Unique ID: 8710213 Medline TA: Arch Gynecol Obstet Country: Germany |
Other Details:
|
Languages: eng Pagination: 335-9 Citation Subset: IM |
Affiliation:
|
Zeynep Kamil Women and Children's Education and Research Hospital, Istanbul, Turkey. astugrul@superonline.com |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Body Weight Cholesterol / blood* Contraceptive Agents, Female / therapeutic use Estradiol / therapeutic use Estrogen Replacement Therapy / methods* Estrogens / therapeutic use Female Humans Lipoproteins / blood* Medroxyprogesterone Acetate / therapeutic use Menopause Middle Aged Norethindrone / analogs & derivatives, therapeutic use Prospective Studies Triglycerides / blood |
| Chemical | |
Reg. No./Substance:
|
0/Contraceptive Agents, Female; 0/Estrogens; 0/Lipoproteins; 0/Triglycerides; 38673-38-0/norethindrone acetate; 50-28-2/Estradiol; 57-88-5/Cholesterol; 68-22-4/Norethindrone; 71-58-9/Medroxyprogesterone Acetate |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Performance of cervicovaginal fetal fibronectin in a community hospital setting.
Next Document: Late secondary syphilis with ulceration of the tongue during HIV coinfection: case report