| Comparison of two fertility-sparing approaches for bilateral borderline ovarian tumours: a randomized controlled study. | |
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MedLine Citation:
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PMID: 17050549 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: During the childbearing years, the standard fertility-sparing treatment for bilateral borderline ovarian tumours (BOTs) is the unilateral oophorectomy plus controlateral cystectomy. The aim of the present study was to compare the effects of two laparoscopic fertility-sparing surgical procedures for the treatment of bilateral BOTs on recurrence and fertility in young women who desire to conceive as soon as possible. METHODS: Thirty-two women affected by bilateral early-stage BOTs who desired to conceive were randomized to receive bilateral cystectomy (experimental group, n=15) or oophorectomy plus controlateral cystectomy (control group, n=17). At the first recurrence after childbearing completion, each patient was treated with non-conservative standard treatment. Recurrences and reproductive events were recorded. RESULTS: After a follow-up period of 81 months (19 inter-quartile; 60-96 range), the cumulative pregnancy rate (CPR) (14/15 versus 9/17; P=0.003) and the cumulative probability of first pregnancy (P= 0.011) were significantly higher in the experimental than in control group. No significant (P=0.358) difference between groups was detected in cumulative probability of first recurrence. CONCLUSIONS: The laparoscopic bilateral cystectomy followed by non-conservative treatment performed at the first recurrence after the childbearing completion is an effective surgical strategy for patients with bilateral early-stage BOTs who desire to conceive as soon as possible. |
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Authors:
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S Palomba; E Zupi; T Russo; A Falbo; S Del Negro; F Manguso; D Marconi; A Tolino; F Zullo |
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Publication Detail:
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Type: Journal Article; Randomized Controlled Trial Date: 2006-10-17 |
Journal Detail:
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Title: Human reproduction (Oxford, England) Volume: 22 ISSN: 0268-1161 ISO Abbreviation: Hum. Reprod. Publication Date: 2007 Feb |
Date Detail:
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Created Date: 2007-01-11 Completed Date: 2007-03-16 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8701199 Medline TA: Hum Reprod Country: England |
Other Details:
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Languages: eng Pagination: 578-85 Citation Subset: IM |
Affiliation:
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Department of Obstetrics and Gynecology, University Magna Graecia of Catanzaro, Catanzaro, Italy. stefanopalomba@tin.it |
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Cystectomy Female Humans Infertility, Female / prevention & control* Laparoscopy Neoplasm Recurrence, Local / surgery Ovarian Neoplasms / pathology, surgery* Ovariectomy Pregnancy Pregnancy Rate* |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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