| Comparison of two different methods for physiologic dead space measurements in ventilated dogs in a clinical setting. | |
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MedLine Citation:
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PMID: 20712605 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To compare physiologic dead space (V(D)) and physiologic dead space to tidal volume (V(T)) ratio (V(D)/V(T)) obtained by an automated single breath test for carbon dioxide (CO(2)) (method SBT) and a manual calculation (method MC) in ventilated healthy dogs. STUDY DESIGN: Prospective clinical study. ANIMALS: Twenty client-owned dogs, ASA I and II undergoing anaesthesia for clinical purposes. METHODS: Following pre-medication, induction of anaesthesia, and intubation of the trachea, intermittent positive pressure ventilation was commenced. Mixed expired CO(2) partial pressure (PēCO(2)) was measured by two methods: method MC by analysis, using an infrared capnograph, of the expired gas collected in a mixing box and method SBT which calculated it automatically by a device consisting of a mainstream capnograph and a pneumotachograph. At four time points arterial partial pressure of CO(2) (PaCO(2)) was measured. Physiologic dead space variables (V(D) and V(D)/V(T)) were calculated manually (method MC) or automatically (method SBT) using the Bohr-Enghoff equation. Method MC and SBT were compared using Bland-Altman plots and linear regression. Intra-class correlation coefficient (ICC) was used to measure consistency of each method. RESULTS: Four measurement pairs were obtained in all 20 dogs for method SBT and MC. The bias was -1.15 mmHg, 7.97 mL and 0.02 for PēCO(2), V(D) and V(D)/V(T), respectively. Linear regression analysis revealed a correlation coefficient (r(2)) of 0.79, 0.94, and 0.83 for PēCO(2), V(D) and V(D)/V(T), respectively. The ICC revealed an excellent consistency for both methods. CONCLUSIONS: The single breath test (SBT) can be used for clinical evaluation of V(D) and V(D)/V(T) in anaesthetized ventilated dogs. CLINICAL RELEVANCE: Through measuring V(D) and V(D)/V(T) important information about lung ventilation can be obtained and the SBT is an easy method to use for this purpose. |
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Authors:
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Martina Mosing; Lukas Staub; Yves Moens |
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Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: Veterinary anaesthesia and analgesia Volume: 37 ISSN: 1467-2995 ISO Abbreviation: Vet Anaesth Analg Publication Date: 2010 Sep |
Date Detail:
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Created Date: 2010-08-17 Completed Date: 2010-11-30 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100956422 Medline TA: Vet Anaesth Analg Country: England |
Other Details:
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Languages: eng Pagination: 393-400 Citation Subset: IM |
Affiliation:
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Faculty of Veterinary Science, The University of Liverpool, Leahurst, Chester High Road, Neston, UK. martina.mosing@gmail.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Carbon Dioxide / blood Dogs / physiology* Female Intermittent Positive-Pressure Breathing / veterinary Male Partial Pressure Respiration, Artificial / veterinary* Respiratory Dead Space / physiology* Respiratory Rate / physiology Tidal Volume / physiology |
| Chemical | |
Reg. No./Substance:
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124-38-9/Carbon Dioxide |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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