| Comparison of two different combination immunosuppressive therapies in the treatment of vogt-koyonagi-harada syndrome. | |
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MedLine Citation:
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PMID: 23323581 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Purpose: To compare the efficacy and safety of cyclosporine/mycophenolate mofetil (CSA/MMF) and cyclosporine/azathioprine (CSA/AZT) in Vogt-Koyonagi-Harada (VKH) patients. Methods: Retrospective comparative case series with follow-up period of at least 1 year. Outcomes include remission rate and corticosteroid-sparing effect. Results: A total of 10 patients were included (5 patients in CSA/MMF, 5 patients in CSA/AZT). The remission rates for CSA/MMF and CSA/AZT were 5.3 and 5.6, respectively (p = .96). The median time to remission was 15 months for CSA/MMF group and 7 months for CSA/AZT group (p = .6419). The rates of corticosteroid-sparing effect were 7.9 and 5.0 for the CSA/MMF and CSA/AZT groups, respectively (p = .65). The median time to corticosteroid-sparing effect was faster in the CSA/AZT group (2 months) compared to the CSA/MMF group (13 months) (p = .9625). Approximately 50% of patients failed with the presented IMT combination regimens. Conclusions: No statistically significant difference was found in the two regimens from the study as presented, although the median time to remission and to corticosteroid-sparing effect was shorter for the CSA/AZT combination. |
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Authors:
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Cheryl A Arcinue; Alaa Radwan; May O Lebanan; C Stephen Foster |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Ocular immunology and inflammation Volume: 21 ISSN: 1744-5078 ISO Abbreviation: Ocul. Immunol. Inflamm. Publication Date: 2013 Feb |
Date Detail:
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Created Date: 2013-01-17 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9312169 Medline TA: Ocul Immunol Inflamm Country: England |
Other Details:
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Languages: eng Pagination: 32-7 Citation Subset: IM |
Affiliation:
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Massachusetts Eye Research and Surgery Institution , Cambridge, Massachusetts , USA. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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