Document Detail


Comparison of two different combination immunosuppressive therapies in the treatment of vogt-koyonagi-harada syndrome.
MedLine Citation:
PMID:  23323581     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Purpose: To compare the efficacy and safety of cyclosporine/mycophenolate mofetil (CSA/MMF) and cyclosporine/azathioprine (CSA/AZT) in Vogt-Koyonagi-Harada (VKH) patients. Methods: Retrospective comparative case series with follow-up period of at least 1 year. Outcomes include remission rate and corticosteroid-sparing effect. Results: A total of 10 patients were included (5 patients in CSA/MMF, 5 patients in CSA/AZT). The remission rates for CSA/MMF and CSA/AZT were 5.3 and 5.6, respectively (p = .96). The median time to remission was 15 months for CSA/MMF group and 7 months for CSA/AZT group (p = .6419). The rates of corticosteroid-sparing effect were 7.9 and 5.0 for the CSA/MMF and CSA/AZT groups, respectively (p = .65). The median time to corticosteroid-sparing effect was faster in the CSA/AZT group (2 months) compared to the CSA/MMF group (13 months) (p = .9625). Approximately 50% of patients failed with the presented IMT combination regimens. Conclusions: No statistically significant difference was found in the two regimens from the study as presented, although the median time to remission and to corticosteroid-sparing effect was shorter for the CSA/AZT combination.
Authors:
Cheryl A Arcinue; Alaa Radwan; May O Lebanan; C Stephen Foster
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Ocular immunology and inflammation     Volume:  21     ISSN:  1744-5078     ISO Abbreviation:  Ocul. Immunol. Inflamm.     Publication Date:  2013 Feb 
Date Detail:
Created Date:  2013-01-17     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9312169     Medline TA:  Ocul Immunol Inflamm     Country:  England    
Other Details:
Languages:  eng     Pagination:  32-7     Citation Subset:  IM    
Affiliation:
Massachusetts Eye Research and Surgery Institution , Cambridge, Massachusetts , USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Uveitis with myasthenia gravis--a rare association.
Next Document:  Pattern of Uveitis in a University-based Referral Center in Southern Thailand.