Document Detail

Comparison of two commercial immunoassays for the detection of anti-rubella IgM and IgG in pediatric patients.
MedLine Citation:
PMID:  17613675     Owner:  NLM     Status:  MEDLINE    
The only threatening modality of rubella is the Congenital Rubella Syndrome that affects fetuses of women who acquire infection during early pregnancy. Laboratory diagnosis is based on serological parameters. We compared anti-rubella IgM and IgG detection of two commercial immunoassay kits (Abbott and Roche). Although we observed an agreement of 97.8% for IgM and 95.7% for IgG when the categories positive, negative and indeterminate were considered, mean titers of IgG and the absorbance/cut off of IgM were statistically different for both kits, thus corroborating the idea that serological results depend very much on the methodology and must be carefully interpreted.
L C Oliveira; T S Okay; K H Kawasato; L P Lima
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of immunoassay & immunochemistry     Volume:  28     ISSN:  1532-1819     ISO Abbreviation:  J Immunoassay Immunochem     Publication Date:  2007  
Date Detail:
Created Date:  2007-07-06     Completed Date:  2007-09-21     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100963688     Medline TA:  J Immunoassay Immunochem     Country:  United States    
Other Details:
Languages:  eng     Pagination:  297-306     Citation Subset:  IM    
Laboratory of Medical Investigation (LIM-36), Department of Pediatrics, School of Medicine, University of São Paulo, Brazil.
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MeSH Terms
Antibodies, Viral / analysis,  blood*
Child, Preschool
Immunoassay / methods*
Immunoglobulin G / analysis,  blood*
Immunoglobulin M / analysis,  blood*
Reagent Kits, Diagnostic*
Rubella / blood,  diagnosis*,  immunology
Reg. No./Substance:
0/Antibodies, Viral; 0/Immunoglobulin G; 0/Immunoglobulin M; 0/Reagent Kits, Diagnostic

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