Document Detail


Comparison of two combined vaccines against typhoid fever and hepatitis A in healthy adults.
MedLine Citation:
PMID:  15519704     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A prospective, randomised, observer-blind, comparative study was performed in healthy adults with a new hepatitis A/typhoid combined vaccine, Viatim, and the marketed Hepatyrix vaccine. Both vaccines induced high levels of protective antibodies, but typhoid responses were higher and hepatitis A responses more rapid with Viatim compared with Hepatyrix. Both vaccines were well tolerated, no serious adverse events (SAEs) occurred, but more Viatim vaccinees had more mild or moderate local reactions (82.7%) than Hepatyrix (53.1%, p < 0.001). In this direct comparison Viatim induced more local reactions, but elicited a more rapid and higher immune response to both antigens than Hepatyrix.
Authors:
Nicholas J Beeching; Paul D Clarke; Nicholas R E Kitchin; Jackie Pirmohamed; Keith Veitch; Françoise Weber
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Vaccine     Volume:  23     ISSN:  0264-410X     ISO Abbreviation:  Vaccine     Publication Date:  2004 Nov 
Date Detail:
Created Date:  2004-11-02     Completed Date:  2005-02-04     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8406899     Medline TA:  Vaccine     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  29-35     Citation Subset:  IM    
Affiliation:
Clinical Research Group, Liverpool School of Tropical Medicine, UK.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Hepatitis A / immunology,  prevention & control
Hepatitis A Vaccines / administration & dosage,  immunology*
Humans
Middle Aged
Prospective Studies
Typhoid Fever / immunology,  prevention & control
Typhoid-Paratyphoid Vaccines / administration & dosage,  immunology*
Vaccines, Combined / administration & dosage,  adverse effects,  immunology*
Chemical
Reg. No./Substance:
0/Hepatitis A Vaccines; 0/Typhoid-Paratyphoid Vaccines; 0/Vaccines, Combined

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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