Document Detail

Comparison of two Papanicolaou staining procedures for automated prescreening.
MedLine Citation:
PMID:  94777     Owner:  NLM     Status:  MEDLINE    
A "regressive" (procedure I) and a "progressive" (procedure II) modification of the Papanicolaou stain were tested for their suitability for automated screening procedures. Intermediate squamous cells and carcinoma cells were scanned with a high-resolution system, and digitized data were statistically analyzed after feature extraction. The regressive modification accentuates the textural features of intermediate squamous cell nuclei as well as the contrast ratio of nucleus and cytoplasm. The progressive modification accentuates some criteria of malignancy, such as polychromasia, hyperchromasia and shifting of nuclear to cytoplasmic ratio. Grouping of data according to patients indicates that the differences found are due to the staining procedures and not to individual variability of parameters in different patients.
H J Soost; E W Falter; K Otto
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Analytical and quantitative cytology     Volume:  1     ISSN:  0190-0471     ISO Abbreviation:  Anal Quant Cytol     Publication Date:    1979 Mar-Apr
Date Detail:
Created Date:  1980-07-28     Completed Date:  1980-07-28     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7911206     Medline TA:  Anal Quant Cytol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  37-42     Citation Subset:  IM    
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MeSH Terms
Cell Nucleus / ultrastructure
Cervix Uteri / cytology*
Chromatin / analysis
Cytological Techniques*
Staining and Labeling / methods*
Uterine Cervical Neoplasms / diagnosis*,  pathology
Vaginal Smears*
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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