| Comparison of tuberculin skin test response after three modalities of neonatal BCG vaccination. | |
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MedLine Citation:
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PMID: 16997338 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The aim of this study was to determine the tuberculin skin test (TST) response to three different BCG modalities [0.1 ml Tokyo (n=104), 0.05 ml Pasteur-Mérieux (n=137) and 0.1 ml Pasteur-Mérieux (n=100)] in a cohort of healthy newborns 5 months after vaccination at birth in Santiago, Chile. Among the 341 infants, 91.2% had a response to TST, and the mean+/-SD TST reaction size was significantly larger in infants receiving the Tokyo strain than in those receiving the 0.05 ml or 0.1 ml Pasteur-Mérieux strains (4.4+/-2.0, 3.5+/-1.3 and 3.1+/-1.4 mm, respectively; P<0.0001). The mean+/-SD of the BCG scar size was significantly lower in infants vaccinated with the Tokyo strain than in those vaccinated with the 0.1 ml Pasteur-Mérieux strain (3.9+/-1.2 vs. 4.3+/-1.1 mm; P=0.03) and no significant difference was found between infants receiving the Tokyo strain and the 0.05 ml Pasteur-Mérieux strain. However, the differences in TST size induced by diverse BCG vaccination modalities may not reflect the quality of the immunologically induced response in terms of TB protection. |
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Authors:
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Jose A Castro-Rodriguez; Javier Mallol; Rosa Andrade; Mónica Muñoz; Ivanna Azzini |
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Publication Detail:
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Type: Comparative Study; Evaluation Studies; Journal Article Date: 2006-09-25 |
Journal Detail:
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Title: Transactions of the Royal Society of Tropical Medicine and Hygiene Volume: 101 ISSN: 0035-9203 ISO Abbreviation: Trans. R. Soc. Trop. Med. Hyg. Publication Date: 2007 May |
Date Detail:
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Created Date: 2007-03-19 Completed Date: 2007-09-18 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7506129 Medline TA: Trans R Soc Trop Med Hyg Country: England |
Other Details:
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Languages: eng Pagination: 493-6 Citation Subset: IM |
Affiliation:
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Department of Pediatric Respiratory Medicine, Faculty of Medical Sciences, Hospital CRS El Pino, University of Santiago de Chile, Santiago, Chile. jacastro17@hotmail.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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BCG Vaccine
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administration & dosage* Dose-Response Relationship, Immunologic Female Follow-Up Studies Humans Infant, Newborn Male Mycobacterium bovis / classification Tuberculin Test* Tuberculosis / immunology, prevention & control* Vaccination / methods |
| Chemical | |
Reg. No./Substance:
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0/BCG Vaccine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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