Document Detail

Comparison of tuberculin skin test and QuantiFERON-TB gold in tube test in patients with chronic inflammatory diseases living in a tuberculosis endemic population.
MedLine Citation:
PMID:  19949831     Owner:  NLM     Status:  MEDLINE    
We aimed to compare tuberculin skin test (TST) and QuantiFERON-TB gold in tube (QFT-IT) in patients with chronic inflammatory diseases living in a population where tuberculosis is endemic and BCG vaccination is routine. Twenty-five patients with rheumatoid arthritis (RA), 16 patients with spondilarthropathy (SpA) and 7 healthy volunteers were recruited in the study. Blood samples were collected for QFT-IT test followed by TST. TST was considered to be positive with an enduration of 5 mm and over in patients with RA and SpA. The cutoff point for TST for the healthy control (HC) was 10 mm. Median TST result of patients who were using immunosuppressive drugs was significantly lower than that of patients who were not [5 (14.5), 13.5 (9.5), respectively, P = 0.04]. Poor agreement between TST and QFT-IT was seen in patients with RA (kappa = 0.141) and in patients with SpA (kappa = 0.190). We found poor concordance between QFT-IT and TST in patients with chronic inflammatory diseases, and TST response was suppressed in patients treated with immunosuppressive drugs.
Feride Gogus; Zafer Günendi; Resul Karakus; Zeynep Erdogan; Kenan Hizel; Fatma Atalay
Publication Detail:
Type:  Comparative Study; Evaluation Studies; Journal Article     Date:  2009-12-01
Journal Detail:
Title:  Clinical and experimental medicine     Volume:  10     ISSN:  1591-9528     ISO Abbreviation:  Clin. Exp. Med.     Publication Date:  2010 Sep 
Date Detail:
Created Date:  2010-08-02     Completed Date:  2010-11-04     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100973405     Medline TA:  Clin Exp Med     Country:  Italy    
Other Details:
Languages:  eng     Pagination:  173-7     Citation Subset:  IM    
Department of Physical Medicine and Rehabilitation, Gazi University, Ankara, Turkey.
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MeSH Terms
Arthritis, Rheumatoid / immunology*
BCG Vaccine / immunology*
Bacteriological Techniques / methods
Chronic Disease
Diagnosis, Differential
Endemic Diseases*
Immunologic Tests / methods*
Middle Aged
Spondylarthritis / immunology*
Tuberculosis / diagnosis*,  epidemiology*,  immunology
Reg. No./Substance:
0/BCG Vaccine

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