Document Detail

Comparison of triphasic waves and epileptic discharges in one patient with genetic epilepsy.
MedLine Citation:
PMID:  23027103     Owner:  NLM     Status:  MEDLINE    
Genetic epilepsies with generalized spike-wave complexes (GSWCs) and encephalopathy triphasic waves (TWs) may resemble each other and have three phases per complex. Electroencephalographic (EEG) interpretation is subjective, and EEGers have noted "TWs" in cases labeled nonconvulsive status epilepticus (NCSE). Direct comparison of both wave forms under the same conditions is rarely possible. In a single patient with generalized spike waves who developed hepatic TWs, morphologic characteristics of both were compared, and it was found that GSWCs have higher frequency first, second, and third phases; steeper phase 2 slope; and briefer after-going slow waves maximal at F3 to F4. Total complex duration was approximately 0.12 seconds. The TWs had dominant high-voltage phases 2 and 3 located more posteriorly, in the frontocentral region, lasting an average of approximately 0.32 seconds. These morphologic distinctions may help differentiate TWs from GSWCs.
Peter W Kaplan; Dan K Schlattman
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Publication Detail:
Type:  Case Reports; Comparative Study; Journal Article    
Journal Detail:
Title:  Journal of clinical neurophysiology : official publication of the American Electroencephalographic Society     Volume:  29     ISSN:  1537-1603     ISO Abbreviation:  J Clin Neurophysiol     Publication Date:  2012 Oct 
Date Detail:
Created Date:  2012-10-02     Completed Date:  2013-03-05     Revised Date:  2013-05-10    
Medline Journal Info:
Nlm Unique ID:  8506708     Medline TA:  J Clin Neurophysiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  458-61     Citation Subset:  IM    
Johns Hopkins University School of Medicine, Baltimore, MD, USA.
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MeSH Terms
Anticonvulsants / administration & dosage
Brain / drug effects,  physiopathology*
Brain Mapping / methods*
Brain Waves* / drug effects,  genetics
Diagnosis, Differential
Epilepsy, Generalized / diagnosis*,  drug therapy,  genetics,  physiopathology
Genetic Predisposition to Disease
Middle Aged
Predictive Value of Tests
Status Epilepticus / diagnosis*,  drug therapy,  genetics,  physiopathology
Time Factors
Valproic Acid / administration & dosage
Reg. No./Substance:
0/Anticonvulsants; 99-66-1/Valproic Acid
Comment In:
J Clin Neurophysiol. 2013 Apr;30(2):210-1   [PMID:  23545775 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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