Document Detail


Comparison of treatment volumes and techniques in prostate cancer radiation therapy.
MedLine Citation:
PMID:  16317275     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: To compare dose-volume histograms (DVHs) for 3 target volumes (group 1, prostate + seminal vesicles + pelvic lymph nodes; group 2, prostate + seminal vesicles; group 3, prostate only) to determine the difference in dose to normal structures (rectum, bladder, and femoral heads) while controlling for target dose using 3-dimensional conformal radiation therapy (3DCRT) versus intensity modulated radiation therapy (IMRT). METHODS: Ten patients with localized prostate cancer were randomly selected. 3DCRT and IMRT planning were done to deliver 75.6 Gy to the prostate, 50.4 Gy to the pelvic nodes, and 55.8 Gy to the seminal vesicles at a standard fractionation of 1.8 Gy. An additional plan delivering 75.6 Gy to the seminal vesicles using IMRT was run. DVHs were compared for 3DCRT and IMRT. RESULTS: In all 3 groups, the percent rectum receiving > or =70 Gy, > or =60 Gy, and > or =40 Gy was significantly less for IMRT than for 3DCRT. Increasing target volumes, as necessary for pelvic nodal irradiation, overall did not result in higher rectal doses for IMRT. With 3DCRT, however, larger target volumes did increase the amount of rectum irradiated. Similar results were obtained for the femoral heads whereas results for the bladder were mixed. CONCLUSION: When compared with 3DCRT, IMRT delivered equivalent or higher doses to the target volume with greater sparing of critical organs. Because dose-volume parameters have been shown to relate to toxicity, IMRT would appear to be the favored technique for prostate cancer radiation, particularly with regard to nodal treatment.
Authors:
Catherine T Lee; Lei Dong; Anesa W Ahamad; Haesun Choi; Rex Cheung; Andrew K Lee; David F Horne; Allan J Breaux; Deborah A Kuban
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Publication Detail:
Type:  Comparative Study; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  American journal of clinical oncology     Volume:  28     ISSN:  1537-453X     ISO Abbreviation:  Am. J. Clin. Oncol.     Publication Date:  2005 Dec 
Date Detail:
Created Date:  2005-11-30     Completed Date:  2006-01-04     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8207754     Medline TA:  Am J Clin Oncol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  618-25     Citation Subset:  IM    
Affiliation:
Department of Radiation Oncology, The University of Texas M. D. Anderson Cancer Center, Houston, TX 77030, USA.
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MeSH Terms
Descriptor/Qualifier:
Dose Fractionation
Dose-Response Relationship, Radiation
Femur Head / radiation effects
Humans
Intestine, Small / radiation effects
Lymph Nodes / pathology,  radiation effects
Lymphatic Irradiation
Male
Organ Specificity
Prostate / pathology,  radiation effects
Prostatic Neoplasms / radiotherapy*
Radiation Injuries / prevention & control
Radiotherapy Dosage
Radiotherapy, Conformal / methods*
Radiotherapy, Intensity-Modulated / methods*
Rectum / radiation effects
Seminal Vesicles / pathology,  radiation effects
Tumor Burden
Urinary Bladder / radiation effects

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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