Document Detail

Comparison of the toxicokinetics between perfluorocarboxylic acids with different carbon chain length.
MedLine Citation:
PMID:  12499116     Owner:  NLM     Status:  MEDLINE    
Toxicokinetics was compared between perfluoroheptanoic acid (PFHA), perfluorooctanoic acid (PFOA), perfluorononanoic acid (PFNA) and perfluorodecanoic acid (PFDA) in male and female rats. Half lives (t(1/2)) in male and female rats were calculated to be 0.10 and 0.05 days, respectively, for PFHA, 5.63 and 0.08 days for PFOA, 29.5 and 2.44 days for PFNA and 39.9 and 58.6 days for PFDA. Total clearance (CL(tot)) of PFHA was higher than those of other perfluorocarboxylic acids (PFCAs) in both male and female rats. By contrast, CL(tot) of PFDA was extremely low in both sexes. PFCAs having shorter carbon chain length showed higher CL(tot). There was a significant sex-related difference in CL(tot) of PFOA and PFNA. Distribution volumes in steady state (V(ss)) were not much different between PFCAs and between sexes. To estimate the role of urinary excretion in plasma clearance of PFCA, renal clearance (CL(R)) was determined for PFCAs. CL(R) of PFCAs were in the order PFHA>PFOA>PFNA approximately equal PFDA and PFHA approximately equal PFOA>PDNA>PFDA in male and female rats, respectively. There was a close relationship between CL(tot) and CL(R) (r(2)=0.981). Plasma protein binding, estimated in vitro, was over 98% for all PFCAs tested. The results indicate that CL(R) is responsible for the difference in CL(tot) between PFCAs having different carbon chain length and between sexes.
Kohtaro Ohmori; Naomi Kudo; Kazunori Katayama; Yoichi Kawashima
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Toxicology     Volume:  184     ISSN:  0300-483X     ISO Abbreviation:  Toxicology     Publication Date:  2003 Mar 
Date Detail:
Created Date:  2002-12-24     Completed Date:  2003-03-18     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0361055     Medline TA:  Toxicology     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  135-40     Citation Subset:  IM    
Faculty of Pharmaceutical Sciences, Josai University, Keyakidai 1-1, Sakado, Saitama, Japan.
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MeSH Terms
Blood Proteins / metabolism
Carboxylic Acids / chemistry,  pharmacokinetics*,  toxicity*
Hydrocarbons, Fluorinated / chemistry,  pharmacology*,  toxicity*
Kidney / metabolism
Protein Binding
Rats, Wistar
Sex Characteristics
Structure-Activity Relationship
Reg. No./Substance:
0/Blood Proteins; 0/Carboxylic Acids; 0/Hydrocarbons, Fluorinated

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