| Comparison of the toxicokinetics between perfluorocarboxylic acids with different carbon chain length. | |
| | |
MedLine Citation:
|
PMID: 12499116 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Toxicokinetics was compared between perfluoroheptanoic acid (PFHA), perfluorooctanoic acid (PFOA), perfluorononanoic acid (PFNA) and perfluorodecanoic acid (PFDA) in male and female rats. Half lives (t(1/2)) in male and female rats were calculated to be 0.10 and 0.05 days, respectively, for PFHA, 5.63 and 0.08 days for PFOA, 29.5 and 2.44 days for PFNA and 39.9 and 58.6 days for PFDA. Total clearance (CL(tot)) of PFHA was higher than those of other perfluorocarboxylic acids (PFCAs) in both male and female rats. By contrast, CL(tot) of PFDA was extremely low in both sexes. PFCAs having shorter carbon chain length showed higher CL(tot). There was a significant sex-related difference in CL(tot) of PFOA and PFNA. Distribution volumes in steady state (V(ss)) were not much different between PFCAs and between sexes. To estimate the role of urinary excretion in plasma clearance of PFCA, renal clearance (CL(R)) was determined for PFCAs. CL(R) of PFCAs were in the order PFHA>PFOA>PFNA approximately equal PFDA and PFHA approximately equal PFOA>PDNA>PFDA in male and female rats, respectively. There was a close relationship between CL(tot) and CL(R) (r(2)=0.981). Plasma protein binding, estimated in vitro, was over 98% for all PFCAs tested. The results indicate that CL(R) is responsible for the difference in CL(tot) between PFCAs having different carbon chain length and between sexes. |
| | |
Authors:
|
Kohtaro Ohmori; Naomi Kudo; Kazunori Katayama; Yoichi Kawashima |
Related Documents
:
|
1115716 - Human amino acid excretion patterns during and following prolonged multistressor tests. 3427776 - Increased excretion of propan-1,3-diol and 3-hydroxypropionic acid apparently caused by... 912856 - Urinary mandelic acid: identified in normal individuals following a single oral load of... 15547796 - Air breathing and ammonia excretion in the giant mudskipper, periophthalmodon schlosseri. 8382836 - Nitric oxide release in response to gut injury. 17033026 - Effect of different forms of methionine on lactational performance of dairy cows. |
Publication Detail:
|
Type: Comparative Study; Journal Article |
Journal Detail:
|
Title: Toxicology Volume: 184 ISSN: 0300-483X ISO Abbreviation: Toxicology Publication Date: 2003 Mar |
Date Detail:
|
Created Date: 2002-12-24 Completed Date: 2003-03-18 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 0361055 Medline TA: Toxicology Country: Ireland |
Other Details:
|
Languages: eng Pagination: 135-40 Citation Subset: IM |
Affiliation:
|
Faculty of Pharmaceutical Sciences, Josai University, Keyakidai 1-1, Sakado, Saitama, Japan. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Blood Proteins / metabolism Carboxylic Acids / chemistry, pharmacokinetics*, toxicity* Female Half-Life Hydrocarbons, Fluorinated / chemistry, pharmacology*, toxicity* Kidney / metabolism Male Protein Binding Rats Rats, Wistar Sex Characteristics Structure-Activity Relationship |
| Chemical | |
Reg. No./Substance:
|
0/Blood Proteins; 0/Carboxylic Acids; 0/Hydrocarbons, Fluorinated |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Intestinal permeability of chlorpyrifos using the single-pass intestinal perfusion method in the rat...
Next Document: Protection against ultraviolet B-induced oxidative DNA damage in rabbit corneal-derived cells (SIRC)...