Document Detail


Comparison of total lung diffusion capacity and the membrane component of diffusion capacity as determined by physiologic and morphometric techniques.
MedLine Citation:
PMID:  6844754     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Morphometric estimates of diffusion capacity have traditionally been calculated for oxygen (DLO2) while physiologic techniques have been used to determine diffusion capacity for carbon monoxide (DLCO). Morphometric estimates of DLCO and Dm were determined for carbon monoxide so that the results can be directly compared to those obtained using physiologic techniques. Multiple gas rebreathing techniques were used to measure total lung diffusion capacity (DLCO), membrane component of diffusion capacity (Dm) and pulmonary capillary blood volume (Vc) in five anesthetized dogs. After the rebreathing measurements were made, the lungs were inflation fixed with glutaraldehyde and subjected to morphometric analysis. The morphometric estimate of diffusion capacity was three times higher than the physiologic estimate. The major components of diffusion capacity, Dm and theta Vc were found to be of approximately equal size when measured physiologically (Dm = 34 and theta Vc = 27 ml X min-1 X mm Hg-1). In contrast, the morphometric estimate of Dm was about six times higher than the morphometric estimate of theta Vc. The widely different ratios of the two major subcomponents of the total lung diffusion capacity as measured by these two different techniques suggest that the same lung function is not being accurately measured by at least one of these two techniques. Differences in results for DLCO cannot be explained by differences in the physiologic state of the animal at the time the measurement was made. Morphometric analysis predicts that Vc is the major term affecting the value of DLCO whereas the physiologic techniques predict that both Dm and Vc contribute substantially to the value of DLCO.
Authors:
J D Crapo; R O Crapo
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Respiration physiology     Volume:  51     ISSN:  0034-5687     ISO Abbreviation:  Respir Physiol     Publication Date:  1983 Feb 
Date Detail:
Created Date:  1983-06-23     Completed Date:  1983-06-23     Revised Date:  2009-11-11    
Medline Journal Info:
Nlm Unique ID:  0047142     Medline TA:  Respir Physiol     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  183-94     Citation Subset:  IM; S    
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MeSH Terms
Descriptor/Qualifier:
Animals
Blood Volume
Capillaries
Dogs
Lung / physiology
Membranes / physiology
Methods
Pulmonary Circulation
Pulmonary Diffusing Capacity*
Grant Support
ID/Acronym/Agency:
HL-23805/HL/NHLBI NIH HHS; HL-25044/HL/NHLBI NIH HHS

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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