| Comparison of topical cyclosporine, punctal occlusion, and a combination for the treatment of dry eye. | |
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MedLine Citation:
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PMID: 17667613 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE: To compare the efficacy of topical cyclosporine, punctal occlusion, and a combination for the treatment of dry eye. METHODS: Patients with dry eye (N = 30) seen in a university-affiliated private practice were randomized to 1 of 3 treatments: cyclosporine 0.05% ophthalmic emulsion (RESTASIS) twice daily, lower-lid punctal plugs (PARASOL), or a plugs-cyclosporine combination. Tear volume, ocular surface staining, and artificial tear use were assessed at baseline and 1, 3, and 6 months. RESULTS: All treatments improved Schirmer scores by 6 months (P < or = 0.005 vs. baseline), with plug-containing regimens favored at 1 and 3 months (P < 0.001 vs. cyclosporine alone). Cyclosporine-containing regimens, but not plugs alone, improved rose bengal staining at 3 and 6 months (P < or = 0.010 vs. baseline). Artificial tear use decreased with plug-containing regimens at 1 month and with all treatments at 3 and 6 months (P < or = 0.005 vs. baseline). Combination therapy produced the greatest overall improvements and was superior to plugs alone in decreasing artificial tear use at 6 months (P = 0.012). CONCLUSIONS: All 3 regimens effectively treated dry eye. Plug-containing regimens increased wetness initially; cyclosporine appeared to promote long-term ocular surface health. The effects may be additive. Patients with punctal occlusion may benefit from adjunctive cyclosporine. |
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Authors:
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Calvin W Roberts; Patricia E Carniglia; Brian G Brazzo |
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Publication Detail:
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Type: Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Cornea Volume: 26 ISSN: 0277-3740 ISO Abbreviation: Cornea Publication Date: 2007 Aug |
Date Detail:
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Created Date: 2007-08-01 Completed Date: 2007-10-16 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8216186 Medline TA: Cornea Country: United States |
Other Details:
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Languages: eng Pagination: 805-9 Citation Subset: IM |
Affiliation:
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Department of Ophthalmology, Weill Medical College of Cornell University, New York, NY, USA. croberts@med.cornell.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Administration, Topical Adult Combined Modality Therapy Cyclosporine / administration & dosage* Dry Eye Syndromes / drug therapy*, metabolism, surgery* Eyelids / surgery* Female Fluorescent Dyes / metabolism Humans Lacrimal Apparatus / surgery* Male Middle Aged Prospective Studies Prostheses and Implants* Rose Bengal / metabolism Tears / metabolism Treatment Outcome |
| Chemical | |
Reg. No./Substance:
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0/Fluorescent Dyes; 11121-48-5/Rose Bengal; 59865-13-3/Cyclosporine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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