Document Detail


Comparison of topical cyclosporine, punctal occlusion, and a combination for the treatment of dry eye.
MedLine Citation:
PMID:  17667613     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
PURPOSE: To compare the efficacy of topical cyclosporine, punctal occlusion, and a combination for the treatment of dry eye. METHODS: Patients with dry eye (N = 30) seen in a university-affiliated private practice were randomized to 1 of 3 treatments: cyclosporine 0.05% ophthalmic emulsion (RESTASIS) twice daily, lower-lid punctal plugs (PARASOL), or a plugs-cyclosporine combination. Tear volume, ocular surface staining, and artificial tear use were assessed at baseline and 1, 3, and 6 months. RESULTS: All treatments improved Schirmer scores by 6 months (P < or = 0.005 vs. baseline), with plug-containing regimens favored at 1 and 3 months (P < 0.001 vs. cyclosporine alone). Cyclosporine-containing regimens, but not plugs alone, improved rose bengal staining at 3 and 6 months (P < or = 0.010 vs. baseline). Artificial tear use decreased with plug-containing regimens at 1 month and with all treatments at 3 and 6 months (P < or = 0.005 vs. baseline). Combination therapy produced the greatest overall improvements and was superior to plugs alone in decreasing artificial tear use at 6 months (P = 0.012). CONCLUSIONS: All 3 regimens effectively treated dry eye. Plug-containing regimens increased wetness initially; cyclosporine appeared to promote long-term ocular surface health. The effects may be additive. Patients with punctal occlusion may benefit from adjunctive cyclosporine.
Authors:
Calvin W Roberts; Patricia E Carniglia; Brian G Brazzo
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Publication Detail:
Type:  Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Cornea     Volume:  26     ISSN:  0277-3740     ISO Abbreviation:  Cornea     Publication Date:  2007 Aug 
Date Detail:
Created Date:  2007-08-01     Completed Date:  2007-10-16     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8216186     Medline TA:  Cornea     Country:  United States    
Other Details:
Languages:  eng     Pagination:  805-9     Citation Subset:  IM    
Affiliation:
Department of Ophthalmology, Weill Medical College of Cornell University, New York, NY, USA. croberts@med.cornell.edu
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MeSH Terms
Descriptor/Qualifier:
Administration, Topical
Adult
Combined Modality Therapy
Cyclosporine / administration & dosage*
Dry Eye Syndromes / drug therapy*,  metabolism,  surgery*
Eyelids / surgery*
Female
Fluorescent Dyes / metabolism
Humans
Lacrimal Apparatus / surgery*
Male
Middle Aged
Prospective Studies
Prostheses and Implants*
Rose Bengal / metabolism
Tears / metabolism
Treatment Outcome
Chemical
Reg. No./Substance:
0/Fluorescent Dyes; 11121-48-5/Rose Bengal; 59865-13-3/Cyclosporine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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