Document Detail

Comparison of tissue plasminogen activator and streptokinase in the management of acute myocardial infarction.
MedLine Citation:
PMID:  2495909     Owner:  NLM     Status:  MEDLINE    
Thrombolysis is well established as effective therapy in AMI. Two thrombolytic agents, streptokinase and tissue plasminogen activator (tPA), are now widely available for clinical use. These agents have different effects, and there has been considerable debate as to which is superior. Both are effective in preserving myocardial function and reducing mortality. However, the confidence limits of these findings overlap, and no firm conclusions can be made from comparing trials enrolling different populations with different baseline characteristics and ancillary treatments such as angioplasty. There have been few "head-to-head" comparisons. These trials show that tPA achieves better lysis rates than streptokinase, but the theoretic advantage of fibrin specificity does not result in fewer adverse effects or greater preservation of LV function. Although each drug may have specific indications, the drugs appear similar in clinical benefit, and further comparison trials are required.
H D White
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Review    
Journal Detail:
Title:  Chest     Volume:  95     ISSN:  0012-3692     ISO Abbreviation:  Chest     Publication Date:  1989 May 
Date Detail:
Created Date:  1989-06-02     Completed Date:  1989-06-02     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0231335     Medline TA:  Chest     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  265S-269S     Citation Subset:  AIM; IM    
Cardiology Department, Green Lane Hospital, Auckland, New Zealand.
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MeSH Terms
Clinical Trials as Topic
Double-Blind Method
Myocardial Infarction / drug therapy*
Myocardial Reperfusion / methods
Random Allocation
Streptokinase / therapeutic use*
Tissue Plasminogen Activator / therapeutic use*
Reg. No./Substance:
EC 3.4.-/Streptokinase; EC Plasminogen Activator

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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