| Comparison of thrombolytic therapy of lower-extremity acute, subacute, and chronic arterial occlusions. | |
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MedLine Citation:
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PMID: 9637438 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Our purpose was to study the effectiveness of thrombolytic therapy in treating acute, subacute, and chronic arterial occlusions in a multicenter retrospective study. Intraarterial urokinase infusion was performed in 235 patients for occluded native arteries. There were 70 (30%) with acute and 26 (5%) with subacute occlusions, and 141 (59%) with chronic symptoms for longer than 3 mo. Complete thrombolysis was achieved in 60 (86%) of the acute, 20 (77%) of the subacute, and 106 (75%) of the chronic occlusions. Adjunctive interventional procedures were performed as needed. Long-term follow-up revealed a primary patency of 87%, 85%, and 76% for the acute, subacute, and chronic occlusion groups, respectively. We conclude that the rate of complete thrombolysis of chronic occlusions proved slightly more efficient for acute and virtually the same for subacute occlusions. Long-term follow-up demonstrated a higher failure rate with chronic than with acute occlusions, probably due to worsened peripheral vascular runoff. |
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Authors:
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M H Wholey; M A Maynar; M H Wholey; J M Pulido-Duque; R Reyes; C R Jarmolowski; W R Castaneda |
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Publication Detail:
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Type: Clinical Trial; Comparative Study; Journal Article; Multicenter Study |
Journal Detail:
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Title: Catheterization and cardiovascular diagnosis Volume: 44 ISSN: 0098-6569 ISO Abbreviation: Cathet Cardiovasc Diagn Publication Date: 1998 Jun |
Date Detail:
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Created Date: 1998-08-18 Completed Date: 1998-08-18 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 7508512 Medline TA: Cathet Cardiovasc Diagn Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 159-69 Citation Subset: IM |
Affiliation:
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Department of Interventional Radiology, Louisiana State University School of Medicine, New Orleans, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acute Disease Aged Angiography Angioplasty Arterial Occlusive Diseases / drug therapy*, radiography, surgery Chronic Disease Endarterectomy Female Follow-Up Studies Humans Infusions, Intra-Arterial Leg / blood supply* Male Middle Aged Plasminogen Activators / administration & dosage* Retrospective Studies Stents Thrombectomy Thrombolytic Therapy* Treatment Outcome Urokinase-Type Plasminogen Activator / administration & dosage* |
| Chemical | |
Reg. No./Substance:
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EC 3.4.21.-/Plasminogen Activators; EC 3.4.21.73/Urokinase-Type Plasminogen Activator |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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