Document Detail

Comparison of three distribution-free procedures in the establishment of assigned values in control sera. The establishment of assigned values in control sera, III.
MedLine Citation:
PMID:  6120204     Owner:  NLM     Status:  MEDLINE    
Distribution-free statistical procedures should be applied to the establishment of assigned values and uncertainty intervals in a control serum. The two problems, how to find an appropriate statistical evaluation procedure and how to find an optimized experimental design, are simultaneously dealt with here: Three distribution-free procedures are presented, each based on elimination of extreme values, and 60 designs are considered differing with respect to the number of reference laboratories, of independent series, and single or double determinations. Using the data of the study described in part 1 of this series (Passing, H. et al. (1981) this j. 19, 1137-1144) we simulated these designs and the pertaining assigned values and uncertainty intervals given by each evaluation procedure. From this study one evaluation procedure is shown to be superior to others. This optimized procedure had the following characteristics: Extreme values are eliminated so that the width of the uncertainty interval is as small as possible. The median of the remaining values is the assigned value. Moreover, 6 reference laboratories are shown to be appropriate.
H Passing
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of clinical chemistry and clinical biochemistry. Zeitschrift für klinische Chemie und klinische Biochemie     Volume:  19     ISSN:  0340-076X     ISO Abbreviation:  J. Clin. Chem. Clin. Biochem.     Publication Date:  1981 Dec 
Date Detail:
Created Date:  1982-04-12     Completed Date:  1982-04-12     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  7701860     Medline TA:  J Clin Chem Clin Biochem     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  1153-66     Citation Subset:  IM    
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MeSH Terms
Alanine Transaminase / blood
Aspartate Aminotransferases / blood
Blood Chemical Analysis*
Blood Glucose / analysis
Creatine / blood
Creatine Kinase / blood
Quality Control
Reference Values*
Statistics as Topic
Urea / analysis
gamma-Glutamyltransferase / blood
Reg. No./Substance:
0/Blood Glucose; 57-00-1/Creatine; 57-13-6/Urea; EC; EC Aminotransferases; EC Transaminase; EC Kinase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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