Document Detail


Comparison of three carbon monoxide monitors for determination of smoking status in smokers and nonsmokers with and without COPD.
MedLine Citation:
PMID:  18158719     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In this (CAMOXI) study, three carbon monoxide (CO) monitors and salivary cotinine are assessed regarding their ability to distinguish smokers from nonsmokers, both in chronic obstructive pulmonary disease (COPD) and healthy people. Twenty-six healthy smokers, 25 healthy nonsmokers, 25 smoking, and 25 former smoking stable COPD patients (age 40-72 years) were included based on self-report (N = 101). All volunteers were measured following a 12-h abstinence period. Sensitivity, specificity, and predictive values of a positive and negative test result were assessed for a range of cutoff points for both CO and salivary cotinine. The prescribed 9-ppm cutoff point of the Breath CO generates a sensitivity of 68% and 42% for COPD patients and healthy people, respectively. Using the prescribed cutoff point (10 ppm) the Smokelyzer produces 56% sensitivity for COPD patients and 23% for healthy people. Both monitors generate 100% specificity in both groups. The cutoff point for the Micro CO meter (5 ppm) generates 88% sensitivity and 92% specificity for COPD patients, and for healthy people 92% and 88%, respectively. The optimal cutoff points depend upon the goal of the test. Salivary cotinine has a 100% sensitivity, specificity, positive predictive value, and negative predictive value over the range of 15 ng/mL through 40 ng/mL for healthy participants and at 10 ng/mL for COPD patients. The prescribed cutoff points for all three CO monitors generate misleading results concerning the determination of the smoking status in both populations. Salivary cotinine measurement outperforms CO measurements and a combination of the two tools is recommended.
Authors:
Lieke Christenhusz; Frans de Jongh; Paul van der Valk; Marcel Pieterse; Erwin Seydel; Job van der Palen
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article    
Journal Detail:
Title:  Journal of aerosol medicine : the official journal of the International Society for Aerosols in Medicine     Volume:  20     ISSN:  0894-2684     ISO Abbreviation:  J Aerosol Med     Publication Date:  2007  
Date Detail:
Created Date:  2007-12-26     Completed Date:  2008-02-21     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8809251     Medline TA:  J Aerosol Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  475-83     Citation Subset:  T    
Affiliation:
University of Twente, Faculty of Behavioral Sciences, Department of Psychology & Communication of Health & Risk, 7500 AE Enschede, The Netherlands. l.c.a.chritenhusz@utwente.nl
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Breath Tests / instrumentation*
Carbon Monoxide / analysis*
Cotinine / analysis*
Female
Humans
Male
Middle Aged
Predictive Value of Tests
Pulmonary Disease, Chronic Obstructive / metabolism*
Saliva / chemistry*
Sensitivity and Specificity
Smoking / metabolism*
Chemical
Reg. No./Substance:
486-56-6/Cotinine; 630-08-0/Carbon Monoxide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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