| Comparison of the therapeutic efficacy of linezolid and vancomycin and correlation of serum and tissue malondialdehyde and myeloperoxidase in an experimental mediastinitis model. | |
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MedLine Citation:
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PMID: 18952240 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: We aimed to investigate the therapeutic efficacy of linezolid in an experimental mediastinitis model and to compare it with vancomycin, which is commonly used. The objective of this study was also to evaluate the role of the immune system in mediastinitis. MATERIALS AND METHODS: Fifty adult Wistar rats were randomly divided into five groups: an uncontaminated and contaminated untreated control groups; a group that received sefazolin prophylaxis; and two groups treated with vancomycin or linezolid. Median sternotomy without access to pleural spaces was performed on all rats. All groups, except the uncontaminated one, were inoculated with 0.5 mL 10(8) colony-forming units/mL methicillin-resistant Staphylococcus aureus in the mediastinal and sternal layers. Postoperatively, vancomycin and linezolid groups were given antibiotic treatment for 7 d, starting 24 h after the end of the procedure. After 7-d treatment tissue samples from the upper ends of the sternotomy line and mediastinum were obtained and evaluated microbiologically. Additionally, serum, heart, lung, liver, kidney, and mediastinal tissues samples were obtained to determine malondialdehyde (MDA) and myeloperoxidase (MPO). RESULTS: The study showed that either vancomycin or linezolid successfully reduced bacterial counts in mediastinum and sternotomy line. MDA and MPO levels were found to be decreased in the treated groups. There was a positive correlation between serum and tissues MDA and MPO in all of the groups. CONCLUSIONS: Our study showed that linezolid appears to be a promising option for treating mediastinitis due to methicillin-resistant S. aureus. Additionally, it was demonstrated that a wide inflammatory process occurred after mediastinitis. |
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Authors:
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Suzan Sacar; Mustafa Sacar; Hulya Aybek; Hüseyin Turgut; Gokhan Onem; Nural Cevahir; Zafer Teke; Ilknur Kaleli; Adem Guler; Alper Ucak; Ahmet Baltalarli |
Publication Detail:
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Type: Comparative Study; Journal Article Date: 2008-05-06 |
Journal Detail:
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Title: The Journal of surgical research Volume: 152 ISSN: 1095-8673 ISO Abbreviation: J. Surg. Res. Publication Date: 2009 Mar |
Date Detail:
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Created Date: 2009-11-03 Completed Date: 2009-12-03 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0376340 Medline TA: J Surg Res Country: United States |
Other Details:
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Languages: eng Pagination: 89-95 Citation Subset: IM |
Affiliation:
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Department of Infectious Diseases and Clinical Microbiology, Faculty of Medicine, Pamukkale University, Denizli, Turkey. suzansacar@yahoo.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Acetamides
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therapeutic use* Animals Anti-Bacterial Agents / therapeutic use* Disease Models, Animal Male Malondialdehyde / metabolism Mediastinitis / drug therapy*, etiology, immunology, metabolism Methicillin-Resistant Staphylococcus aureus Oxazolidinones / therapeutic use* Peroxidase / metabolism Rats Rats, Wistar Vancomycin / therapeutic use* |
| Chemical | |
Reg. No./Substance:
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0/Acetamides; 0/Anti-Bacterial Agents; 0/Oxazolidinones; 1404-90-6/Vancomycin; 165800-03-3/linezolid; 542-78-9/Malondialdehyde; EC 1.11.1.7/Peroxidase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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