| Comparison of the therapeutic effects of leflunomide and mycophenolate mofetil in the treatment of immunoglobulin A nephropathy manifesting with nephrotic syndrome. | |
| | |
MedLine Citation:
|
PMID: 20650041 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
OBJECTIVE: To evaluate the therapeutic effects and safety of a combination therapy of leflunomide (LEF) and prednisone for the treatment of immunoglobulin A (IgA) nephropathy manifesting with nephrotic syndrome. METHODS: 40 patients with IgA nephropathy manifesting with nephrotic syndrome were randomly divided into two groups. The treatment group was administered with a combination therapy of prednisone and LEF, and the control group with a combination therapy of prednisone and MMF. For the following comparison 24-h urinary protein excretion and the serum levels of albumin, cholesterol, and creatinine before and after the therapy were assessed. RESULTS: In the treatment group, the medication was markedly effective in 5 cases and effective in 7 cases; the total efficacy rate was 60.0%. In the control group, the treatment was markedly effective in 5 cases and effective in 8 cases; the total efficacy rate was 65.0%. The IgA levels in both groups decreased after therapy. There were no significant differences between the results for the two groups (p > 0.05). The treatments were well tolerated in both groups. CONCLUSION: LEF is a safe and effective drug for the treatment of IgA nephropathy manifesting with nephrotic syndrome. |
| | |
Authors:
|
X W Liu; D M Li; G S Xu; S R Sun |
Publication Detail:
|
Type: Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: International journal of clinical pharmacology and therapeutics Volume: 48 ISSN: 0946-1965 ISO Abbreviation: Int J Clin Pharmacol Ther Publication Date: 2010 Aug |
Date Detail:
|
Created Date: 2010-07-23 Completed Date: 2010-09-02 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 9423309 Medline TA: Int J Clin Pharmacol Ther Country: Germany |
Other Details:
|
Languages: eng Pagination: 509-13 Citation Subset: IM |
Affiliation:
|
Department of Nephrology, and 2Information Section, Xijing Hospital, The Fourth Military Medical University, Xi'an, China. liuxiaow@fmmu.edu.cn |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adolescent Adult Anti-Inflammatory Agents / adverse effects, therapeutic use Drug Therapy, Combination Female Glomerulonephritis, IGA / drug therapy*, physiopathology Humans Immunoglobulin A / blood Immunosuppressive Agents / adverse effects, therapeutic use* Isoxazoles / adverse effects, therapeutic use* Male Middle Aged Mycophenolic Acid / adverse effects, analogs & derivatives*, therapeutic use Nephrotic Syndrome / drug therapy, etiology Prednisone / adverse effects, therapeutic use Treatment Outcome Young Adult |
| Chemical | |
Reg. No./Substance:
|
0/Anti-Inflammatory Agents; 0/Immunoglobulin A; 0/Immunosuppressive Agents; 0/Isoxazoles; 128794-94-5/mycophenolate mofetil; 24280-93-1/Mycophenolic Acid; 53-03-2/Prednisone; 75706-12-6/leflunomide |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Screening for G71R mutation of the UDP-glucuronosyltransferase 1 (UGT1A1) gene in neonates with path...
Next Document: Irreversible sensorineural hearing loss: an unusual side effect of non-steroidal anti-inflammatory d...