Document Detail


Comparison of the therapeutic effects of different compositions of muskone in the treatment of experimental myocardial infarct in rats and analgesia in mice.
MedLine Citation:
PMID:  18729258     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The aim of this study was to compare the therapeutic effects of muskone, a traditional preparation containing slender Dutchmanspipe root (MCS) used to treat angina pectoris and related conditions, muskone containing inula root (MCI) in place of MCS, and muskone (M) without either slender Dutchmanspipe root (S) or inula root (I) on acute myocardial infarct (AMI) in rats and the pain response in mice. The AMI model was established by ligating the left anterior descending coronary artery (LAD). The AMI rats were treated with MCS, MCI, M, S and I, respectively, before the surgical operation. Plasma endothelin (ET), 6-keto-prostaglandin F(1alpha) (6-keto-PGF(1alpha)), thromboxane (TXB(2)) and myocardial apoptosis were detected, the ratio of 6-keto-PGF(1alpha) level to TXB(2) level (6-keto-PGF(2alpha)/TXB(2)) was calculated, and the infarct size was determined. In the pain relieving study, the prophylactic treatments with MCS, MCI, M, S, I and aspirin were administered to the mice once a day for 5 days, the response latency and the number of abdominal contractions after the stimulus of intraperitoneal injection of acetic acid were recorded. The results show that MCS, MCI and M significantly ameliorated plasma ET, TXB(2), 6-keto-PGF(1alpha) and 6-keto-PGF(2alpha)/TXB(2) levels, reduced infarct size and opposed myocardial apoptosis. Simultaneously, they also significantly reduced the abdominal contractions and also prolonged the response latency induced by acetic acid in the mice. S and I only showed a degree of relieving pain, but their efficacy was weaker than that of MCS, MCI and M, and they had little cardioprotective effect. In conclusion, MCS, MCI and M had a significant cardioprotective and analgesic effect, and they had similar efficacy. S and I only had a secondary analgesic effect. Removing S from the MCS or replacing S with I did not influence the cardioprotective effect and analgesic effect.
Authors:
Yikui Li; Jinyan Zhang; Lianda Li
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Retracted Publication    
Journal Detail:
Title:  Phytotherapy research : PTR     Volume:  22     ISSN:  1099-1573     ISO Abbreviation:  Phytother Res     Publication Date:  2008 Sep 
Date Detail:
Created Date:  2008-09-10     Completed Date:  2008-12-18     Revised Date:  2009-05-21    
Medline Journal Info:
Nlm Unique ID:  8904486     Medline TA:  Phytother Res     Country:  England    
Other Details:
Languages:  eng     Pagination:  1219-23     Citation Subset:  IM    
Affiliation:
Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing, China.
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MeSH Terms
Descriptor/Qualifier:
Analgesics / therapeutic use*
Animals
Cycloparaffins / chemistry,  therapeutic use*
In Situ Nick-End Labeling
Mice
Myocardial Infarction / drug therapy*,  pathology
Pain / drug therapy*
Rats
Chemical
Reg. No./Substance:
0/Analgesics; 0/Cycloparaffins; 541-91-3/muscone
Comments/Corrections
Retraction In:
Phytother Res. 2009 May;23(5):745   [PMID:  19391126 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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