Document Detail

Comparison of thallium-201 and technetium-99m methoxyisobutyl isonitrile.
MedLine Citation:
PMID:  1442570     Owner:  NLM     Status:  MEDLINE    
Thallium-201 (201Tl) is a well-established radionuclide used in myocardial perfusion imaging for assessing the presence and prognostic significance of coronary artery disease. Recently, technetium-99m hexakis-2-methoxyisobutyl isonitrile (99mTc-sestamibi) has become available for the same diagnostic and prognostic procedures. This discussion compares the imaging characteristics and clinical applications of 201Tl with those of 99mTc-sestamibi. There is a strong diagnostic concordance between the 2 agents in symptomatic patients. Various comparative clinical trials have shown in numerous patients that both agents have a similar diagnostic yield in both planar and single-photon emission computed tomography (SPECT) imaging. Because of better image quality of the 99mTc agent, there is a trend toward better specificity and normalcy rate, in comparison to 201Tl. However, when using reinjection imaging protocols, 201Tl retains a unique place as an imaging agent to identify viable myocardium.
F J Wackers
Publication Detail:
Type:  Comparative Study; Journal Article; Review    
Journal Detail:
Title:  The American journal of cardiology     Volume:  70     ISSN:  0002-9149     ISO Abbreviation:  Am. J. Cardiol.     Publication Date:  1992 Nov 
Date Detail:
Created Date:  1992-12-10     Completed Date:  1992-12-10     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0207277     Medline TA:  Am J Cardiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  30E-34E     Citation Subset:  AIM; IM    
Department of Diagnostic Radiology, Yale University School of Medicine, New Haven, Connecticut 06510.
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MeSH Terms
Coronary Disease / radionuclide imaging*
Coronary Vessels / radionuclide imaging
Sensitivity and Specificity
Technetium Tc 99m Sestamibi / diagnostic use*
Thallium Radioisotopes / diagnostic use*
Tomography, Emission-Computed, Single-Photon
Reg. No./Substance:
0/Thallium Radioisotopes; 109581-73-9/Technetium Tc 99m Sestamibi

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