| Comparison of synthesis and secretion of plasma albumin, fibrinogen and alpha 2-macroglobulin by slices of Morris hepatomas and rat liver. | |
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MedLine Citation:
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PMID: 6158979 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Slices of rat liver or Morris Hepatomas 5123 GVI and 7777 were incubated for 2 h with 14C-leucine. Newly synthesized labelled proteins were determined independently in the medium and tissue homogenate, total protein after precipitation with trichloro-acetic acid, and albumin, fibrinogen and alpha 2-macroglobulin after immuno-precipitation with monospecific antisera. In comparison with control rat liver, synthesis and secretion of albumin were reduced four- to five-fold in the 2 heptomas examined. On the other hand, synthesis and secretio of fibrinogen and alpha 2-macroglobulin in Hepatomas 5123 GVI annd 7777 were similar to rat liver, especially to the liver isolated from rats with turpentine-induced local inflammation. |
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Authors:
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A Koj |
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Publication Detail:
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Type: Comparative Study; In Vitro; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: British journal of experimental pathology Volume: 61 ISSN: 0007-1021 ISO Abbreviation: Br J Exp Pathol Publication Date: 1980 Jun |
Date Detail:
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Created Date: 1981-01-16 Completed Date: 1981-01-16 Revised Date: 2012-05-07 |
Medline Journal Info:
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Nlm Unique ID: 0372543 Medline TA: Br J Exp Pathol Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 332-8 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Fibrinogen / biosynthesis*, secretion Leucine / metabolism Liver / metabolism*, secretion Liver Neoplasms, Experimental / metabolism*, secretion Male Rats Serum Albumin / biosynthesis*, secretion alpha-Macroglobulins / biosynthesis*, secretion |
| Chemical | |
Reg. No./Substance:
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0/Serum Albumin; 0/alpha-Macroglobulins; 61-90-5/Leucine; 9001-32-5/Fibrinogen |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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