Document Detail


Comparison of symptomatic and asymptomatic reinfarctions after small subcortical stroke.
MedLine Citation:
PMID:  8033939     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We compared possible factors leading to symptomatic and asymptomatic reinfarcts in 207 patients an average of 2.1 years after their index atherothrombotic stroke presenting with small subcortical infarcts. Symptomatic reinfarcts were mostly small infarcts in the perforating artery regions associated with angiographic evidence of atherosclerosis of parent arteries (large-artery disease), a high hematocrit, elevated fibrinogen and Lp(a) levels. They occurred with insufficient inhibition of platelet aggregability in patients receiving antiplatelet medication. In contrast, many asymptomatic reinfarcts were small perforator infarcts not associated with large-artery disease or cortical infarcts, and occurred in the absence of hematologic risk markers, and in spite of sufficient inhibition of platelet aggregability.
Authors:
H Tohgi; K Chiba; H Takahashi; K Tamura; K Sasaki; H Suzuki
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  European neurology     Volume:  34     ISSN:  0014-3022     ISO Abbreviation:  Eur. Neurol.     Publication Date:  1994  
Date Detail:
Created Date:  1994-08-12     Completed Date:  1994-08-12     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0150760     Medline TA:  Eur Neurol     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  140-6     Citation Subset:  IM    
Affiliation:
Department of Neurology, Iwate Medical University, Japan.
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MeSH Terms
Descriptor/Qualifier:
Aged
Aspirin / administration & dosage,  adverse effects
Cerebral Angiography*
Cerebral Infarction / blood,  drug therapy,  radiography*
Cholesterol, HDL / blood
Female
Fibrinogen / metabolism
Follow-Up Studies
Hematocrit
Humans
Intracranial Arteriosclerosis / blood,  drug therapy,  radiography
Lipoprotein(a) / blood
Male
Middle Aged
Neurologic Examination / drug effects
Recurrence
Risk Factors
Ticlopidine / administration & dosage,  adverse effects
Tomography, X-Ray Computed*
Chemical
Reg. No./Substance:
0/Cholesterol, HDL; 0/Lipoprotein(a); 50-78-2/Aspirin; 55142-85-3/Ticlopidine; 9001-32-5/Fibrinogen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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