Document Detail

Comparison of sublingual captopril, nifedipine and prazosin in hypertensive emergencies during hemodialysis.
MedLine Citation:
PMID:  8247194     Owner:  NLM     Status:  MEDLINE    
Hypertensive emergencies in hemodialysis require immediate therapy, usually by parenteral drug administration; however, sublingual medications may have potential in this special condition. Sublingual captopril (25 mg), nifedipine (10 mg) and prazosin (2 mg) were prescribed to determine the effectiveness and safety of each medication in the treatment of hypertensive emergencies during hemodialysis. Blood pressure and heart rate were measured continuously up to 120 min postdose. The response rates were 83% for captopril, 90% for nifedipine and 11% for prazosin. The significant hypotensive effects of both sublingual captopril and nifedipine occurred at 10 min and continued up to 120 min. The reduction of systolic blood pressure occurred earlier in nifedipine than captopril (10 vs. 15 min). No significant difference in heart rate between them was noted. There were no side effects in the captopril group but flushing, tachycardia and headache were observed in 4 patients of the nifedipine group. We concluded that sublingual captopril and nifedipine were effective but captopril seemed to have less side effects than nifedipine and may be an excellent alternative to sublingual nifedipine in the urgent treatment of hypertensive emergencies in hemodialysis. Prazosin was not recommended because of its low response rate.
S G Wu; S L Lin; W Y Shiao; H W Huang; C F Lin; Y H Yang
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Multicenter Study; Randomized Controlled Trial    
Journal Detail:
Title:  Nephron     Volume:  65     ISSN:  0028-2766     ISO Abbreviation:  Nephron     Publication Date:  1993  
Date Detail:
Created Date:  1994-01-05     Completed Date:  1994-01-05     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0331777     Medline TA:  Nephron     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  284-7     Citation Subset:  IM    
Department of Internal Medicine, Municipal Women and Childrens General Hospital, Kaohsiung, ROC.
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MeSH Terms
Administration, Sublingual
Blood Pressure / drug effects
Captopril / administration & dosage*
Chemistry, Pharmaceutical
Heart Rate / drug effects
Hypertension / drug therapy*,  etiology
Middle Aged
Nifedipine / administration & dosage*,  pharmacokinetics
Prazosin / administration & dosage*
Renal Dialysis / adverse effects*
Reg. No./Substance:
19216-56-9/Prazosin; 21829-25-4/Nifedipine; 62571-86-2/Captopril

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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