Document Detail

Comparison of subgroups assigned to medical regimens used to suppress cardiac ischemia (the Asymptomatic Cardiac Ischemia Pilot [ACIP] Study).
MedLine Citation:
PMID:  8677870     Owner:  NLM     Status:  MEDLINE    
This report focuses on the subset of 235 patients from the Asymptomatic Cardiac Ischemia Pilot (ACIP) study receiving randomly assigned medical therapy to treat angina and suppress ischemia detected on ambulatory electrocardiography: 121 patients received the sequence of atenolol and nifedipine, and 114 diltiazem and isosorbide dinitrate. After 12 weeks of therapy, the primary end point (absence of ambulatory electrocardiographic (ECG) ischemia and no clinical events) was reached in 47% of atenolol/nifedipine- versus 31% of diltiazem/isosorbide dinitrate-treated patients (adjusted p = 0.03). A trend to increased exercise time to ST depression was seen in the atenolol and nifedipine versus diltiazem and isosorbide dinitrate regimens (median treadmill duration 5.8 vs 4.8 minutes; p = 0.04). However, when adjusted for baseline imbalances in ambulatory ECG ischemia, the 2 medical combinations were similar in suppression of ambulatory ECG ischemia. In both medication regimens, an association between mean heart rate and ischemia on ambulatory electrocardiography after 12 weeks of treatment was observed so that patients on either regimen with a mean heart rate > 80 beats/min had ischemia detectable almost twice as often as those with a mean heart rate < 70 beats/min (p < 0.001).
C M Pratt; R P McMahon; S Goldstein; C J Pepine; T C Andrews; I Dyrda; W H Frishman; N L Geller; J A Hill; N A Morgan; P H Stone; G L Knatterud; G Sopko; C R Conti
Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The American journal of cardiology     Volume:  77     ISSN:  0002-9149     ISO Abbreviation:  Am. J. Cardiol.     Publication Date:  1996 Jun 
Date Detail:
Created Date:  1996-08-15     Completed Date:  1996-08-15     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0207277     Medline TA:  Am J Cardiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1302-9     Citation Subset:  AIM; IM    
Department of Medicine, Baylor College of Medicine, Houston, Texas, USA.
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MeSH Terms
Angina Pectoris / diagnosis,  drug therapy
Atenolol / therapeutic use*
Case-Control Studies
Delayed-Action Preparations
Diltiazem / therapeutic use*
Drug Therapy, Combination
Electrocardiography, Ambulatory
Exercise Test
Exercise Tolerance / drug effects
Heart Rate / drug effects
Isosorbide Dinitrate / therapeutic use*
Middle Aged
Myocardial Ischemia / diagnosis,  drug therapy*
Nifedipine / therapeutic use*
Pilot Projects
Prospective Studies
Time Factors
Grant Support
Reg. No./Substance:
0/Delayed-Action Preparations; 21829-25-4/Nifedipine; 29122-68-7/Atenolol; 42399-41-7/Diltiazem; 87-33-2/Isosorbide Dinitrate

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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