| Comparison of steady state pulmonary diffusing capacity estimates for O2 and CO in dogs. | |
| | |
MedLine Citation:
|
PMID: 6777846 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
In view of the fact that the inhomogeneity effects on pulmonary diffusing capacity (DL) estimates are quite different for O2 and for CO, simultaneous determinations of steady-state DLCO and DLO2 were attempted and compared. To this end, pulmonary gas exchange was measured in 17 anesthetized and artificially ventilated dogs, in hypoxia with and without carbon monoxide in inspired gas (FIO2 = 0.12, FICO = 0.0009 to 0.0016). The diffusing capacity estimates were computed by two conventional procedures, the first (Dapp) taking into account the mean alveolar partial pressures and the second (DVDA) the ideal alveolar partial pressures. It was found that the presence of COHb in blood, inevitable in the steady-state DLCO procedure, leads to a marked underestimation of DLO2; therefore DLCO values could only be adequately compared to DLO2 values obtained in the absence of CO from inspired gas. These DLO2 were 18.5 and 33.4 mumol . min-1 . Torr-1 . kg-1 for the mean DappO2 and DVDAO2, respectively, whereas the DLCO values obtained after 15 to 25 min CO inspiration were 30.0 and 83.4 mumol . min-1 . Torr-1 . kg-1 for the mean DappCO and the mean DVDACO, respectively. The salient feature is that with both procedures the mean value of DLCO estimate is higher than the corresponding DLO2 estimate. This finding suggests that in anesthetized, artificially ventilated dogs DappO2 and DVDACO estimates obtained by steady-state procedures in hypoxia are largely influenced by inhomogeneity effects and of limited value for assessment of the diffusing properties of the lung. DappCO and DVDAO2 are also affected by inhomogeneities but to a lesser degree. |
| | |
Authors:
|
J Savoy; M C Michoud; M Robert; J Geiser; P Haab; J Piiper |
Related Documents
:
|
17873026 - Hemodynamics and muscle sympathetic nerve activity after 8 h of sustained hypoxia in he... 890556 - Reduction of hypoxic pulmonary vasoconstriction by diethyl ether in the isolated perfus... 16285606 - The threshold of the intermittent hypoxic exposure period to elicit polycythemia in rats. 12091176 - Laryngeal muscle activities with cerebral hypoxia-ischemia in newborn lambs. 2705866 - Evidence for the failure of the laplace law as a sole explanation for wall thickening o... 2925356 - Protective effect of branched chain-enriched amino acid formulation in myocardial ische... |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Respiration physiology Volume: 42 ISSN: 0034-5687 ISO Abbreviation: Respir Physiol Publication Date: 1980 Oct |
Date Detail:
|
Created Date: 1981-02-24 Completed Date: 1981-02-24 Revised Date: 2009-11-11 |
Medline Journal Info:
|
Nlm Unique ID: 0047142 Medline TA: Respir Physiol Country: NETHERLANDS |
Other Details:
|
Languages: eng Pagination: 43-59 Citation Subset: IM |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Anoxia / physiopathology Carbon Dioxide* Dogs Mathematics Oxygen* Pulmonary Diffusing Capacity* |
| Chemical | |
Reg. No./Substance:
|
124-38-9/Carbon Dioxide; 7782-44-7/Oxygen |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Alveolar-capillary equilibration kinetics of 13CO2 in human lungs studied by rebreathing.
Next Document: Ossification of the posterior longitudinal ligament