Document Detail

Comparison of the stability of topical isotretinoin and topical tretinoin and their efficacy in acne.
MedLine Citation:
PMID:  2971693     Owner:  NLM     Status:  MEDLINE    
After 4 hours of exposure to incandescent light, 80% of 0.05% topical isotretinoin and 60% of 0.05% topical tretinoin preparations remained in their original form. In contrast, after 2 hours of exposure to fluorescent light only 25% of topical tretinoin and possibly 60% of topical isotretinoin remained in their original forms. Longer exposure to fluorescent light did not result in further breakdown, and the final breakdown of both preparations was similar. A 12-week, double-blind clinical trial comparing isotretinoin (0.05%) with tretinoin (0.05%) applied topically to patients with moderate acne was carried out. Both preparations caused significant reductions in papules and pustules. However, neither treatment was significantly superior to the other in the reduction of acne lesions. This may be because both preparations are rapidly broken down to similar products when exposed to fluorescent light.
D J Elbaum
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Controlled Clinical Trial; Journal Article    
Journal Detail:
Title:  Journal of the American Academy of Dermatology     Volume:  19     ISSN:  0190-9622     ISO Abbreviation:  J. Am. Acad. Dermatol.     Publication Date:  1988 Sep 
Date Detail:
Created Date:  1988-11-07     Completed Date:  1988-11-07     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7907132     Medline TA:  J Am Acad Dermatol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  486-91     Citation Subset:  IM    
Department of Dermatology, Stanford University Medical Center, CA.
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MeSH Terms
Acne Vulgaris / drug therapy*
Administration, Cutaneous
Chromatography, High Pressure Liquid
Double-Blind Method
Drug Stability
Isotretinoin / administration & dosage*,  analysis
Random Allocation
Tretinoin / administration & dosage*,  analysis
Reg. No./Substance:
302-79-4/Tretinoin; 4759-48-2/Isotretinoin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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