| Comparison of spectroscopically measured tissue alcohol concentration to blood and breath alcohol measurements. | |
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MedLine Citation:
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PMID: 19895140 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Alcohol testing is an expanding area of interest due to the impacts of alcohol abuse that extend well beyond drunk driving. However, existing approaches such as blood and urine assays are hampered in some testing environments by biohazard risks. A noninvasive, in vivo spectroscopic technique offers a promising alternative, as no body fluids are required. The purpose of this work is to report the results of a 36-subject clinical study designed to characterize tissue alcohol measured using near-infrared spectroscopy relative to venous blood, capillary blood, and breath alcohol. Comparison of blood and breath alcohol concentrations demonstrated significant differences in alcohol concentration [root mean square of 9.0 to 13.5 mg/dL] that were attributable to both assay accuracy and precision as well as alcohol pharmacokinetics. A first-order kinetic model was used to estimate the contribution of alcohol pharmacokinetics to the differences in concentration observed between the blood, breath, and tissue assays. All pair-wise combinations of alcohol assays were investigated, and the fraction of the alcohol concentration variance explained by pharmacokinetics ranged from 41.0% to 83.5%. Accounting for pharmacokinetic concentration differences, the accuracy and precision of the spectroscopic tissue assay were found to be comparable to those of the blood and breath assays. |
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Authors:
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Trent D Ridder; Benjamin J Ver Steeg; Bentley D Laaksonen |
Publication Detail:
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Type: Comparative Study; Evaluation Studies; Journal Article; Research Support, N.I.H., Extramural |
Journal Detail:
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Title: Journal of biomedical optics Volume: 14 ISSN: 1560-2281 ISO Abbreviation: J Biomed Opt Publication Date: 2009 Sep-Oct |
Date Detail:
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Created Date: 2009-11-09 Completed Date: 2010-01-13 Revised Date: 2010-11-02 |
Medline Journal Info:
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Nlm Unique ID: 9605853 Medline TA: J Biomed Opt Country: United States |
Other Details:
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Languages: eng Pagination: 054039 Citation Subset: IM |
Affiliation:
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TruTouch Technologies, Inc., 800 Bradbury South East, Suite 219, Albuquerque, New Mexico 87106, USA. Trent.Ridder@TruTouchTechnologies.com |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Alcoholism / diagnosis* Blood Chemical Analysis / methods* Breath Tests / methods* Ethanol / analysis* Female Humans Male Middle Aged Reproducibility of Results Sensitivity and Specificity Spectroscopy, Near-Infrared / methods* Substance Abuse Detection / methods* Young Adult |
| Chemical | |
Reg. No./Substance:
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64-17-5/Ethanol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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