| Comparison of some of the physicochemical characteristics of type 2 diabetic and normal human bones: a sample study. | |
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MedLine Citation:
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PMID: 20801059 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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AIM: The aim of this study was to compare some of the physicochemical characteristics of type 2 diabetic bones (DBs) and normal bones (NBs). MATERIALS AND METHODS: The organic and inorganic parts of human NBs and DBs were separated using conventional methods, and their physicochemical characteristics were compared using infrared (IR) spectroscopy, sodium dodecyl sulfate-polyacrylamide gel electrophoresis, thermogravimetric analysis, X-ray diffraction (XRD), and scanning electron microscopy (SEM). RESULTS: The IR spectrum of the collagen part of DBs has showed the presence of carbonyl groups, indicating cross-linking in the α-chain. This was also confirmed by the increased thermal stability (22°C) in DB collagen. The XRD data of the inorganic part of DBs have revealed decreased crystallinity. SEM images of the inorganic part of DBs have shown a porous (weak) nature compared to those of NBs, which exhibited a compact (healthy) nature. CONCLUSION: The cross-linking in DB collagen molecules and the decreased and defective crystallinity in the inorganic portion of DBs might be the reasons for the increased risk of fracture among diabetic patients. |
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Authors:
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Santhanam Sekar; Annamalai Chandrasekaran; Urmila Rao; Thotapalli Parvathaleswara Sastry |
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Publication Detail:
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Type: Journal Article Date: 2010-08-30 |
Journal Detail:
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Title: Journal of diabetes and its complications Volume: 25 ISSN: 1873-460X ISO Abbreviation: J. Diabetes Complicat. Publication Date: 2011 May-Jun |
Date Detail:
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Created Date: 2011-04-19 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9204583 Medline TA: J Diabetes Complications Country: United States |
Other Details:
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Languages: eng Pagination: 187-92 Citation Subset: IM |
Copyright Information:
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Copyright © 2011 Elsevier Inc. All rights reserved. |
Affiliation:
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Bio-products Laboratory, Central Leather Research Institute, Chennai 600 020, India. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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