Document Detail

Comparison of some effects of acetylsalicylic acid and rofecoxib during orthodontic tooth movement.
MedLine Citation:
PMID:  15014407     Owner:  NLM     Status:  MEDLINE    
The purpose of this study was to examine the effects of 2 different anti-inflammatory drugs on gingival crevicular fluid (GCF) volume and on prostaglandin E(2) (PGE(2)) levels of the GCF during orthodontic tooth movement. A total of 36 extraction patients, aged 17.6 +/- 2.5 years (mean +/- standard deviation), were divided into 3 groups. Acetylsalicylic acid (aspirin) and rofecoxib (Vioxx, Merck, Whitehouse Station, NJ) were used for pain control in the first and second groups; the third group was used as a control. Gingival crevicular fluid was sampled at the beginning of tooth movement and at 24, 48, and 168 hours. An automated enzyme immunoassay was used to measure PGE(2) in GCF. The intragroup differences were evaluated with the Wilcoxon test, and the differences between the groups were determined with the Mann-Whitney U test. Gingival crevicular fluid volumes of the groups did not change significantly during the experimental period. Depending on the variations of fibroblast activation, PGE(2) levels of all the groups increased at 24 and 48 hours and decreased at 168 hours. When the drugs were compared, it was found that the inhibition effect of aspirin on PGE(2) was more than that of rofecoxib. The results suggest that rofecoxib can be used during orthodontic treatment, but further study is recommended.
Emel Sari; Hüseyin Olmez; A Umit Gürton
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  American journal of orthodontics and dentofacial orthopedics : official publication of the American Association of Orthodontists, its constituent societies, and the American Board of Orthodontics     Volume:  125     ISSN:  0889-5406     ISO Abbreviation:  Am J Orthod Dentofacial Orthop     Publication Date:  2004 Mar 
Date Detail:
Created Date:  2004-03-11     Completed Date:  2004-04-07     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8610224     Medline TA:  Am J Orthod Dentofacial Orthop     Country:  United States    
Other Details:
Languages:  eng     Pagination:  310-5     Citation Subset:  D; IM    
Department of Orthodontics, Kasimpasa Military Hospital, Istanbul, Turkey.
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MeSH Terms
Anti-Inflammatory Agents, Non-Steroidal / therapeutic use*
Aspirin / therapeutic use*
Cyclooxygenase Inhibitors / therapeutic use*
Dinoprostone / analysis
Follow-Up Studies
Gingival Crevicular Fluid / chemistry,  drug effects
Lactones / therapeutic use*
Pain, Postoperative / prevention & control
Serial Extraction
Statistics, Nonparametric
Tooth Movement*
Reg. No./Substance:
0/Anti-Inflammatory Agents, Non-Steroidal; 0/Cyclooxygenase Inhibitors; 0/Lactones; 0/Sulfones; 0/rofecoxib; 363-24-6/Dinoprostone; 50-78-2/Aspirin

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