Document Detail

Comparison of sodium nitroprusside and isoprenaline aerosols in histamine-induced bronchial asthma of the guinea pig.
MedLine Citation:
PMID:  471074     Owner:  NLM     Status:  MEDLINE    
1. Sodium nitroprusside (NP) is a potent relaxant of the guinea pig's tracheal smooth muscle contracted by carbachol or histamine. 2. At high doses, aerosols of NP delay the occurrence of symptoms of bronchial asthma in guinea pigs subjected to a histamine aerosol. However, the beta-adrenergic bronchodilator isoprenaline is at least 2,600 times more potent as an anti-asthmatic than NP on a molar basis. 3 NP and isoprenaline both reduce the blood pressure in rats when given either as infusion or as aerosol. The aerosol/infusion dosage ratio for comparable reductions of blood pressure were 1 for isoprenaline, and 10 for NP. After cessation of the application of the NP aerosol, the blood pressure rose more than twice as fast (t1/2 of blood pressure recovery) than after cessation of the application of the isoprenaline aerosol. 4. The poor antiasthmatic effect of NP aerosols may result from low permeability of the bronchial epithelium to the NP anion, from partial destruction in the airways or during tissue permeation, and from short half life of NP in the circulating blood. 5. Because of its inferiority to known bronchodilators, aerosols of NP cannot be recommended for the treatment of acute bronchial asthma.
V A Kreye; E Marquard
Related Documents :
14642134 - Protective effects of alpha 1-antitrypsin on acute lung injury in rabbits induced by en...
8526694 - Pathogenesis and treatment of the adult respiratory distress syndrome.
17480144 - European consensus guidelines on the management of neonatal respiratory distress syndrome.
471074 - Comparison of sodium nitroprusside and isoprenaline aerosols in histamine-induced bronc...
8070944 - Characterization of left ventricle function by analysis of pressure responses to steps ...
18632704 - Relation of iron and red meat intake to blood pressure: cross sectional epidemiological...
Publication Detail:
Type:  Comparative Study; In Vitro; Journal Article    
Journal Detail:
Title:  Naunyn-Schmiedeberg's archives of pharmacology     Volume:  306     ISSN:  0028-1298     ISO Abbreviation:  Naunyn Schmiedebergs Arch. Pharmacol.     Publication Date:  1979 Apr 
Date Detail:
Created Date:  1979-10-24     Completed Date:  1979-10-24     Revised Date:  2010-03-12    
Medline Journal Info:
Nlm Unique ID:  0326264     Medline TA:  Naunyn Schmiedebergs Arch Pharmacol     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  203-7     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Asthma / chemically induced,  drug therapy*
Ferricyanides / therapeutic use*
Guinea Pigs
Histamine / pharmacology*
Isoproterenol / administration & dosage,  therapeutic use*
Nitroprusside / administration & dosage,  therapeutic use*
Reg. No./Substance:
0/Aerosols; 0/Ferricyanides; 15078-28-1/Nitroprusside; 51-45-6/Histamine; 7683-59-2/Isoproterenol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Evidence for the bilobal nature of diferric rabbit plasma transferrin.
Next Document:  Baclofen and muscimol: behavioural and neurochemical sequelae of unilateral intranigral administrati...