Document Detail


Comparison of slow-release pindolol, standard pindolol, and propranolol in angina pectoris.
MedLine Citation:
PMID:  6404149     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Twenty-two patients with chronic, stable, exercise-induced angina pectoris were assessed during periods of therapy with propranolol, standard-formulation pindolol, and a slow-release preparation of pindolol. Patients maintained diaries of the frequency of angina pectoris and nitroglycerin consumption and underwent treadmill exercise testing at 2 weekly intervals. No significant differences were observed in nitroglycerin consumption or anginal frequency during these 3 treatment programs. Resting heart rates were higher with pindolol than with propranolol, but no differences were noted between periods on standard and slow-release pindolol. Systolic and diastolic blood pressures were similar during therapy with these 3 treatment programs. Treadmill walking time to the development of moderate angina and systolic and diastolic blood pressure was similar during treatment with propranolol, standard-formulation pindolol, and slow-release pindolol. Exercise heart rates were slightly higher during therapy with slow-release pindolol than during standard-formulation pindolol. It is concluded that propranolol, pindolol, and slow-release pindolol are equally effective in the management of patients with chronic, stable, exercise-induced angina.
Authors:
J O Parker
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Publication Detail:
Type:  Clinical Trial; Journal Article    
Journal Detail:
Title:  The American journal of cardiology     Volume:  51     ISSN:  0002-9149     ISO Abbreviation:  Am. J. Cardiol.     Publication Date:  1983 Apr 
Date Detail:
Created Date:  1983-05-05     Completed Date:  1983-05-05     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0207277     Medline TA:  Am J Cardiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1062-6     Citation Subset:  AIM; IM    
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Angina Pectoris / drug therapy*
Chronic Disease
Clinical Trials as Topic
Delayed-Action Preparations
Double-Blind Method
Exercise Test
Hemodynamics / drug effects
Humans
Male
Middle Aged
Nitroglycerin / administration & dosage
Pindolol / administration & dosage*
Propranolol / administration & dosage*
Time Factors
Chemical
Reg. No./Substance:
0/Delayed-Action Preparations; 13523-86-9/Pindolol; 525-66-6/Propranolol; 55-63-0/Nitroglycerin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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