Document Detail

Comparison of slow-release indomethacin and diflunisal in patients with arthrosis.
MedLine Citation:
PMID:  6510016     Owner:  NLM     Status:  MEDLINE    
A double-blind, crossover study was carried out in 44 patients with osteoarthrosis of the hip or knee to compare the efficacy and tolerability of treatment with a new slow-release formulation of indomethacin (50 mg) with that of diflunisal (250 mg). After a 1-week wash-out period, patients were allocated at random to receive 2 tablets daily of one or other preparation for 6 weeks before being crossed over to the alternative drug for a further 6 weeks. Aspirin was allowed as a rescue analgesic throughout the study. Subjective assessments of pain and objective assessments of joint mobility were made before the start of treatment and at the end of each period, and details were recorded of rescue analgesic usage and any side-effects. Analysis of the results from 42 patients showed that whilst both treatments helped to alleviate pain, patients' overall evaluation of efficacy at the end of the study indicated that indomethacin was slightly more effective than diflunisal and there was a significant preference for indomethacin. Both drugs were well tolerated and none of the side-effects, reported in about 15% of patients on each drug, resulted in any withdrawals.
A Gordin; I Karppinen; K Holttinen
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Current medical research and opinion     Volume:  9     ISSN:  0300-7995     ISO Abbreviation:  Curr Med Res Opin     Publication Date:  1984  
Date Detail:
Created Date:  1985-02-21     Completed Date:  1985-02-21     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0351014     Medline TA:  Curr Med Res Opin     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  275-9     Citation Subset:  IM    
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MeSH Terms
Delayed-Action Preparations
Diflunisal / administration & dosage*,  adverse effects,  therapeutic use
Indomethacin / administration & dosage*,  adverse effects,  therapeutic use
Middle Aged
Osteoarthritis / drug therapy*
Salicylic Acids / administration & dosage*
Reg. No./Substance:
0/Delayed-Action Preparations; 0/Salicylic Acids; 22494-42-4/Diflunisal; 53-86-1/Indomethacin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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