Document Detail


Comparison of sirolimus-eluting stent and paclitaxel-eluting stent for long-term cardiac adverse events in diabetic patients: the Korean Multicenter Angioplasty Team (KOMATE) Registry.
MedLine Citation:
PMID:  18942123     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: There is some controversy on long-term cardiac outcomes between sirolimus-eluting stents (SES) and paclitaxel-eluting stents (PES) in diabetes mellitus (DM). We compared cardiac adverse events after SES and PES implantation in patients with DM over a period of 3 year. METHODS: A total of 634 patients with DM treated with SES (n = 428) or PES (n = 206) were consecutively enrolled in the KOMATE registry from 2003 to 2004. We assessed major adverse cardiac events (MACEs, cardiovascular death, nonfatal myocardial infarction, ischemia driven target vessel revascularization) and stent thrombosis (ST) according to the definitions set by the Academic Research Consortium. RESULTS: Propensity score (PS) analysis was performed to adjust different baseline characteristics. The mean follow-up duration was 38 +/- 8 month (at least 36 month and up to 53 month). The 3-year MACE rate did not show a significant difference between the two groups [52 (12.1%) in SES vs. 29 (14.1%) in PES, P = 0.496]. The definite and probable ST at 3 year were similar in both SES and PES [12 (2.8%) in SES vs. 7 (3.4%) in PES, P = 0.681]. There were no differences in hazard ratio for MACE and ST between two stents [MACE, crude: 0.844 (0.536-1.330) and adjusted for PS: 0.858 (0.530-1.389); ST, crude: 0.820 (0.323-2.083) and adjusted for PS: 0.960 (0.357-2.587)]. CONCLUSIONS: The present study demonstrated that long-tem cardiac outcomes including ST were not significantly different between SES and PES in patients with DM.
Authors:
Jung-Sun Kim; Byoung Ho Lee; Young-Guk Ko; Donghoon Choi; Yangsoo Jang; Pil-Ki Min; Young-Won Yoon; Bum Kee Hong; Hyuck Moon Kwon; Min-Soo Ahn; Seung-Hwan Lee; Jung Han Yoon; Byoung Kwon Lee; Byung Ok Kim; Byeong-Kuk Kim; Sung Jin Oh; Dong Woon Jeon; Joo Young Yang; Jung Rae Cho; Jae-Hun Jung; Seung-Ki Ryu;
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Publication Detail:
Type:  Comparative Study; Journal Article; Multicenter Study    
Journal Detail:
Title:  Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions     Volume:  72     ISSN:  1522-726X     ISO Abbreviation:  Catheter Cardiovasc Interv     Publication Date:  2008 Nov 
Date Detail:
Created Date:  2008-10-30     Completed Date:  2009-01-23     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100884139     Medline TA:  Catheter Cardiovasc Interv     Country:  United States    
Other Details:
Languages:  eng     Pagination:  601-7     Citation Subset:  IM    
Copyright Information:
(c) 2008 Wiley-Liss, Inc.
Affiliation:
Yonsei Cardiovascular Center, Seoul, Republic of Korea.
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Aged, 80 and over
Angioplasty, Transluminal, Percutaneous Coronary* / adverse effects,  instrumentation,  mortality
Cardiovascular Agents / administration & dosage*
Cardiovascular Diseases / etiology,  mortality,  prevention & control*
Coronary Angiography
Coronary Stenosis / mortality,  radiography,  therapy*
Diabetes Complications / mortality,  radiography,  therapy*
Disease-Free Survival
Drug-Eluting Stents*
Female
Humans
Korea
Male
Middle Aged
Paclitaxel / administration & dosage*
Registries
Risk Assessment
Sirolimus / administration & dosage*
Time Factors
Treatment Outcome
Chemical
Reg. No./Substance:
0/Cardiovascular Agents; 33069-62-4/Paclitaxel; 53123-88-9/Sirolimus
Investigator
Investigator/Affiliation:
J-S Kim / ; B H Lee / ; Y-G Ko / ; D Choi / ; Y Jang / ; P K Min / ; Y-W Yoon / ; B K Hong / ; H M Kwon / ; M-S Ahn / ; S-H Lee / ; J H Yoon / ; K Kwon / ; S H Park / ; Y S Byun / ; B K Lee / ; C W Ko / ; B K Kim / ; S J Oh / ; D W Jeon / ; J Y Yang / ; S-K Ryu / ; J R Cho / ; J-H Jung / ; N H Lee /
Comments/Corrections
Comment In:
Catheter Cardiovasc Interv. 2008 Nov 1;72(5):610-1   [PMID:  18949774 ]
Catheter Cardiovasc Interv. 2008 Nov 1;72(5):608-9   [PMID:  18949773 ]

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