Document Detail

Comparison of single photon emission computed tomography findings in cases of healthy adults and solvent-exposed adults.
MedLine Citation:
PMID:  8986248     Owner:  NLM     Status:  MEDLINE    
Single photon emission computed tomography (SPECT) is a useful tool in measuring dynamic brain functioning. Its potential to reveal the physiological mechanisms of neurotoxicity has not been fully explored. In the present study, the SPECT findings for 25 healthy control subjects were compared to the findings for 25 mixed organic solvent exposure subjects. Specific physiological abnormalities related to regional cerebral blood flow activity (rCBF) were revealed. In the early phase of uptake, significantly decreased uptake was found in the mixed organic solvent group; in the late phase of uptake, a significant increase in uptake was found in specific regions of interest. The discovery of this abnormality in brain functioning may be a significant step toward the creation of a biological marker of neurotoxicity. Early detection of neurotoxicity is important in occupational medicine to prevent neurotoxic illnesses in working populations.
C E Fincher; T S Chang; E H Harrell; M C Kettelhut; W J Rea; A Johnson; D C Hickey; T R Simon
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  American journal of industrial medicine     Volume:  31     ISSN:  0271-3586     ISO Abbreviation:  Am. J. Ind. Med.     Publication Date:  1997 Jan 
Date Detail:
Created Date:  1997-03-12     Completed Date:  1997-03-12     Revised Date:  2006-02-27    
Medline Journal Info:
Nlm Unique ID:  8101110     Medline TA:  Am J Ind Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  4-14     Citation Subset:  IM    
University of North Texas, Denton, USA.
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MeSH Terms
Brain / drug effects,  metabolism*,  radionuclide imaging
Case-Control Studies
Cerebrovascular Circulation / drug effects*
Middle Aged
Occupational Exposure
Reference Values
Solvents / pharmacology*
Tomography, Emission-Computed, Single-Photon*
Reg. No./Substance:
Comment In:
Am J Ind Med. 1997 Dec;32(6):695-701   [PMID:  9358930 ]
Erratum In:
Am J Ind Med 1997 Dec;32(6):693-4

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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