| Comparison of single photon emission computed tomography findings in cases of healthy adults and solvent-exposed adults. | |
| | |
MedLine Citation:
|
PMID: 8986248 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Single photon emission computed tomography (SPECT) is a useful tool in measuring dynamic brain functioning. Its potential to reveal the physiological mechanisms of neurotoxicity has not been fully explored. In the present study, the SPECT findings for 25 healthy control subjects were compared to the findings for 25 mixed organic solvent exposure subjects. Specific physiological abnormalities related to regional cerebral blood flow activity (rCBF) were revealed. In the early phase of uptake, significantly decreased uptake was found in the mixed organic solvent group; in the late phase of uptake, a significant increase in uptake was found in specific regions of interest. The discovery of this abnormality in brain functioning may be a significant step toward the creation of a biological marker of neurotoxicity. Early detection of neurotoxicity is important in occupational medicine to prevent neurotoxic illnesses in working populations. |
| | |
Authors:
|
C E Fincher; T S Chang; E H Harrell; M C Kettelhut; W J Rea; A Johnson; D C Hickey; T R Simon |
Related Documents
:
|
1122508 - Design and function of a mechanical assembly for recording echocardiograms during uprig... 11918128 - Does exercise-induced severe ischaemia result in elevation of plasma troponin-t level i... 12920568 - Usefulness of thallium-201 muscle scan to investigate perfusion reserve in the lower li... 8475868 - Exercise thallium scintigraphy versus high-dose dipyridamole echocardiography testing f... 23669008 - The effects of exercise training on fitness, mobility, fatigue, and health related qual... 19964868 - Imaging of forearm-muscle activities by cp-mct and tr-dot. |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: American journal of industrial medicine Volume: 31 ISSN: 0271-3586 ISO Abbreviation: Am. J. Ind. Med. Publication Date: 1997 Jan |
Date Detail:
|
Created Date: 1997-03-12 Completed Date: 1997-03-12 Revised Date: 2006-02-27 |
Medline Journal Info:
|
Nlm Unique ID: 8101110 Medline TA: Am J Ind Med Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 4-14 Citation Subset: IM |
Affiliation:
|
University of North Texas, Denton, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Brain / drug effects, metabolism*, radionuclide imaging Case-Control Studies Cerebrovascular Circulation / drug effects* Female Humans Male Middle Aged Occupational Exposure Reference Values Solvents / pharmacology* Tomography, Emission-Computed, Single-Photon* |
| Chemical | |
Reg. No./Substance:
|
0/Solvents |
| Comments/Corrections | |
Comment In:
|
Am J Ind Med. 1997 Dec;32(6):695-701
[PMID:
9358930
]
|
Erratum In:
|
Am J Ind Med 1997 Dec;32(6):693-4 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: The efficacy of E.P.D., a new immunotherapy, in the treatment of allergic diseases in children.
Next Document: Occupational risks for the development of brain tumors.