| Comparison of silicon-coated nylon suture to plain nylon suture in the rat middle cerebral artery occlusion model. | |
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MedLine Citation:
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PMID: 16569436 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A variety of intraluminal sutures have been used in the middle cerebral artery occlusion model (MCAO) of focal ischemia. In the present study we tested commercially available silicon-coated nylon suture in the MCAO model and compared the results to traditional monofilament nylon suture occlusion. Twelve Sprague-Dawley male rats were randomly divided two groups, MCAO with 4-0 nylon suture (Group N, n=6) and MCAO with silicone-coated 4-0 nylon suture (Group S, n=6). Rats were sacrificed 24 h after reperfusion. Assessment included mortality rates, neurological evaluation, and infarct volume. One rat died in each group from subarachanoid hemorrhage. Neurological evaluation demonstrated that Group S tended to have worse neurological outcomes than Group N, although this difference was not statistically significant. On TTC stain Group S had significantly larger infarct volumes than Group N. We conclude that the commercially available silicone-coated occlusion suture provides better occlusion of the middle cerebral artery than the traditional uncoated nylon suture. Classification: Disease-related neuroscience (Section 6). |
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Authors:
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Norihito Shimamura; Gerald Matchett; Tamiji Tsubokawa; Hiroki Ohkuma; John Zhang |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, N.I.H., Extramural Date: 2006-03-29 |
Journal Detail:
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Title: Journal of neuroscience methods Volume: 156 ISSN: 0165-0270 ISO Abbreviation: J. Neurosci. Methods Publication Date: 2006 Sep |
Date Detail:
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Created Date: 2006-08-24 Completed Date: 2006-11-14 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 7905558 Medline TA: J Neurosci Methods Country: Netherlands |
Other Details:
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Languages: eng Pagination: 161-5 Citation Subset: IM |
Affiliation:
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Department of Physiology and Pharmacology, Loma Linda University School of Medicine, Loma Linda, CA 92350, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Behavior, Animal / physiology Brain / pathology Brain Ischemia / pathology, psychology Infarction, Middle Cerebral Artery / pathology*, psychology Ligation Male Middle Cerebral Artery / physiology* Nylons* Rats Rats, Sprague-Dawley Silicon* Sutures* |
| Grant Support | |
ID/Acronym/Agency:
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HD43120/HD/NICHD NIH HHS; NS43338/NS/NINDS NIH HHS; NS45694/NS/NINDS NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Nylons; 7440-21-3/Silicon |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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